Adolescent alcohol abuse is associated with continued substance abuse into adulthood, and the public health burden of adolescent drinking is evident in its association with drunk driving, unwanted and risky sexual behavior, truncated educational achievement, altered life trajectories, and premature death. To reduce that public health burden with appropriate interventions, we must understand why these adult outcomes associate with adolescent alcohol exposure. The obstacles in drawing causal inferences from observational data are well-known;potential confounds in the association of adolescent drinking with adverse adult outcomes are many, and the available data do not permit confident causal inferences. Using the unusual resources available to us from decades of longitudinal research with Finnish twins, we propose studies designed to document the consequences of adolescent alcohol use across the lifespan, comparing outcomes in exposure-discordant twin pairs to address the question of whether adult consequences of adolescent drinking are causal in nature, or whether, instead, they arise from selection processes and correlated liabilities. Exposure-discordant co-twins, critically including adequate numbers of exposure-discordant monozygotic co-twins, can yield incisive information with which to evaluate this question. We will obtain and analyze data from four large Finnish cohorts longitudinally studied for substance use from entry ages 12-22, tracking adult outcomes to ages 25-59. Our research plan will yield informative data for individual-based analyses on 22,000 individuals and robust analyses of exposure-discordant co-twins on 1,250 twin pairs, including a substantial subset of the most informative: monozygotic co-twins who are discordant for their alcohol exposure in adolescence. Results of this innovative research will provide important information on the meaning of long-term adult associations with adolescent alcohol abuse, inform intervention efforts, and address a major public health burden.

Public Health Relevance

Alcohol-exposure during adolescence is associated with adverse outcomes in adulthood. But the meaning of that association remains uncertain. We propose studies of adult twin pairs discordant for adolescent alcohol exposure to critically evaluate whether the association is causal or not.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
2R01AA012502-11A1
Application #
8503785
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Witt, Ellen
Project Start
2000-06-01
Project End
2018-05-31
Budget Start
2013-08-15
Budget End
2014-05-31
Support Year
11
Fiscal Year
2013
Total Cost
$254,400
Indirect Cost
$65,405
Name
Indiana University Bloomington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Latvala, Antti; Rose, Richard J; Pulkkinen, Lea et al. (2014) Childhood verbal development and drinking behaviors from adolescence to young adulthood: a discordant twin-pair analysis. Alcohol Clin Exp Res 38:457-65
Aaltonen, Sari; Kujala, Urho M; Kaprio, Jaakko (2014) Factors behind leisure-time physical activity behavior based on Finnish twin studies: the role of genetic and environmental influences and the role of motives. Biomed Res Int 2014:931820
Rose, Richard J; Winter, Torsten; Viken, Richard J et al. (2014) Adolescent alcohol abuse and adverse adult outcomes: evaluating confounds with drinking-discordant twins. Alcohol Clin Exp Res 38:2314-21
van den Berg, Stéphanie M; de Moor, Marleen H M; McGue, Matt et al. (2014) Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behav Genet 44:295-313
Jelenkovic, Aline; Bogl, Leonie H; Rose, Richard J et al. (2014) Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: exploring common genetic and environmental factors. Atherosclerosis 233:394-402
Meyers, Jacquelyn L; Salvatore, Jessica E; Vuoksimaa, Eero et al. (2014) Genetic influences on alcohol use behaviors have diverging developmental trajectories: a prospective study among male and female twins. Alcohol Clin Exp Res 38:2869-77
Latvala, Antti; Rose, Richard J; Pulkkinen, Lea et al. (2014) Drinking, smoking, and educational achievement: cross-lagged associations from adolescence to adulthood. Drug Alcohol Depend 137:106-13
Boraska, V; Franklin, C S; Floyd, J A B et al. (2014) A genome-wide association study of anorexia nervosa. Mol Psychiatry 19:1085-94
Salmela-Aro, Katariina; Read, Sanna; Vuoksimaa, Eero et al. (2014) Depressive symptoms and career-related goal appraisals: genetic and environmental correlations and interactions. Twin Res Hum Genet 17:236-43
He, Liang; Sillanpää, Mikko J; Ripatti, Samuli et al. (2014) Bayesian latent variable collapsing model for detecting rare variant interaction effect in twin study. Genet Epidemiol 38:310-24

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