We propose to extend and enrich a large longitudinal study of alcohol and other substance use disorders from adolescence through young adulthood that has been funded by NIAAA since 1991. Five waves of extensive diagnostic, medical, substance use and psychosocial functioning data have been collected from 565 adolescents from addictions treatment programs and a community comparison group of 220 youth: at baseline;at 1-year, 3-year, and 5-year follow-ups;and at age 25. The current project is designed to support continued analyses of this unique data set to study the long-term clinical course of adolescent-onset alcohol and drug problems and comorbid psychopathology;to extend this project to an age 30 assessment and study outcomes particularly relevant to this age;and, to support the collection of participants'DNA for current and future studies of genetic polymorphisms associated with alcohol and drug problem phenotypes. The age 30 assessment will include detailed self-report and interview data, DNA samples, a urine drug screen, a physical exam, and blood tests for HIV, HSV-2 and liver injury. Longitudinal data will be used to test two specific aims: 1) to characterize the validity of diagnostic criteria for AUDs/SUDs, and to determine pathways and predictors of the clinical course of these disorders, from adolescence through age 30;2) to determine how adolescent and young adult substance use and problems affect and are affected by educational and occupational achievement, marriage, cohabitation and parenting. We also will describe and explore racial differences in young adult outcomes among African-Americans and Caucasians recruited from addictions treatment as teens. Very little work has addressed these important issues in clinical samples. The proposed research directly addresses NIAAA strategic priorities regarding the longitudinal study of adolescence and young adulthood;the importance of research on diagnostic criteria and comorbid psychopathology;the collection of DNA and the development of novel phenotypes in clinical research studies;and the study of racial differences in the effects of substance problems. The multidisciplinary research team has expertise in cross-fertilizing areas such as psychiatry, developmental psychopathology, genetics, statistics, criminal justice and public health. Our results will be directly translatable to clinical practice and public health policy. The extensive extant database (e.g., 3031 assessments in 785 subjects to date), the investigators'history of productivity and the emerging results regarding young adult outcomes of adolescent-onset addiction make this a highly feasible, critically important and cost-effective longitudinal project. Public Health Relevance: This project will study the Nosology and clinical course of alcohol and substance use disorders from adolescence through age 30. We will examine the effects of substance problem trajectories on young adult psychosocial functioning and potential racial disparities in these outcomes. The results will increase our understanding of how to prevent and treat adolescent and young adult substance disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA013397-10
Application #
8308007
Study Section
Special Emphasis Panel (ZRG1-RPHB-B (02))
Program Officer
Ruffin, Beverly
Project Start
2002-03-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2012
Total Cost
$354,371
Indirect Cost
$117,215
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Black, Jessica J; Chung, Tammy (2014) Mechanisms of change in adolescent substance use treatment: how does treatment work? Subst Abus 35:344-51
Martin, Christopher S; Langenbucher, James W; Chung, Tammy et al. (2014) Truth or consequences in the diagnosis of substance use disorders. Addiction 109:1773-8
Cornelius, Jack; Kirisci, Levent; Reynolds, Maureen et al. (2014) Does stress mediate the development of substance use disorders among youth transitioning to young adulthood? Am J Drug Alcohol Abuse 40:225-9
Chung, Tammy; Martin, Christopher S; Maisto, Stephen A et al. (2012) Greater prevalence of proposed DSM-5 nicotine use disorder compared to DSM-IV nicotine dependence in treated adolescents and young adults. Addiction 107:810-8
Chung, Tammy; Maisto, Stephen A; Mihalo, Anthony et al. (2011) Brief assessment of readiness to change tobacco use in treated youth. J Subst Abuse Treat 41:137-47
Martin, Christopher S; Steinley, Douglas L; Verges, Alvaro et al. (2011) The proposed 2/11 symptom algorithm for DSM-5 substance-use disorders is too lenient. Psychol Med 41:2008-10
Winters, Ken C; Martin, Chris S; Chung, Tammy (2011) Substance use disorders in DSM-V when applied to adolescents. Addiction 106:882-4; discussion 895-7
Clark, Duncan B; Thatcher, Dawn L; Martin, Christopher S (2010) Child abuse and other traumatic experiences, alcohol use disorders, and health problems in adolescence and young adulthood. J Pediatr Psychol 35:499-510
Cornelius, Jack R; Aizenstein, Howard J; Hariri, Ahmad R (2010) Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression. Addict Behav 35:644-6
Martin, Christopher S; Chung, Tammy; Langenbucher, James W (2008) How should we revise diagnostic criteria for substance use disorders in the DSM-V? J Abnorm Psychol 117:561-75

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