Research on the course of alcohol and substance problems in treated adolescents is limited largely to 1-year outcomes, Further, little is known about mechanisms of change underlying reductions in substance use because existing studies preclude fine-grained temporal analysis of substance use patterns, The proposed project will use intensive, time-limited short term follow-up over 1-year, combined with longer-term follow-up through 2-years to identify factors influencing course of substance use and problems, with an emphasis on alcohol, cannabis and tobacco. We will prospectively study a total of 300 adolescents (age 14-18), each with a parent collateral informant: 200 adolescents will be recruited from addictions treatment and 100 adolescents will be recruited from the community. The community sample will serve as a reference group to determine the clinical significance of changes observed in clinical participants. All adolescents will be assessed at baseline (within I week of treatment entry for clinical subjects). 6-, 12-, 18-, and 24-months. Clinical adolescents also will complete monthly phone follow-ups during the first year of follow-up. Monthly follow-along data during the first follow-up year and longer-term follow-up through 2-years will be used to address three specific aims: (1) to develop and validate a model of the course of substance use and problems that integrates shorter-term processes of response, remission, and relapse with longer-term processes of recovery and recurrence, (2) to characterize the time course and factors associated with the onset of different course processes for alcohol, cannabis and nicotine, (3) to identify pathways and predictors of the course of substance problems in treated youth. Results will provide important new information that will enhance the timing and content of substance use interventions for adolescents.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA014357-04
Application #
7194302
Study Section
Special Emphasis Panel (ZAA1-BB (01))
Program Officer
Lowman, Cherry
Project Start
2004-06-01
Project End
2009-02-28
Budget Start
2007-03-01
Budget End
2008-02-29
Support Year
4
Fiscal Year
2007
Total Cost
$334,410
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Mahabir, Samantha; Chatterjee, Dipashree; Misquitta, Keith et al. (2018) Lasting changes induced by mild alcohol exposure during embryonic development in BDNF, NCAM and synaptophysin-positive neurons quantified in adult zebrafish. Eur J Neurosci 47:1457-1473
Seguin, Diane; Gerlai, Robert (2018) Fetal alcohol spectrum disorders: Zebrafish in the analysis of the milder and more prevalent form of the disease. Behav Brain Res 352:125-132
Spinola, Suzanne; Park, Aesoon; Maisto, Stephen A et al. (2017) Motivation Precedes Goal Setting in Prediction of Cannabis Treatment Outcomes in Adolescents. J Child Adolesc Subst Abuse 26:132-140
Chung, Tammy; Cornelius, Jack; Clark, Duncan et al. (2017) Greater Prevalence of Proposed ICD-11 Alcohol and Cannabis Dependence Compared to ICD-10, DSM-IV, and DSM-5 in Treated Adolescents. Alcohol Clin Exp Res 41:1584-1592
Cornelius, Jack R; Chung, Tammy; Douaihy, Antoine B et al. (2016) Mirtazapine in comorbid major depression and an alcohol use disorder: A double-blind placebo-controlled pilot trial. Psychiatry Res 242:326-330
Tran, S; Facciol, A; Gerlai, R (2016) The Zebrafish, a Novel Model Organism for Screening Compounds Affecting Acute and Chronic Ethanol-Induced Effects. Int Rev Neurobiol 126:467-84
Seguin, Diane; Shams, Soaleha; Gerlai, Robert (2016) Behavioral Responses to Novelty or to a Predator Stimulus Are Not Altered in Adult Zebrafish by Early Embryonic Alcohol Exposure. Alcohol Clin Exp Res 40:2667-2675
Chung, Tammy; Maisto, Stephen A (2016) Time-varying associations between confidence and motivation to abstain from marijuana during treatment among adolescents. Addict Behav 57:62-8
Chung, Tammy; Sealy, Lauren; Abraham, Margaret et al. (2015) Personal Network Characteristics of Youth in Substance Use Treatment: Motivation for and Perceived Difficulty of Positive Network Change. Subst Abus 36:380-8
Chung, Tammy; Ferrell, Robert; Clark, Duncan B (2015) Indirect association of DAT1 genotype with executive function through white matter volume in orbitofrontal cortex. Psychiatry Res 232:76-83

Showing the most recent 10 out of 55 publications