Social influences, such as family environment and peer characteristics, are relatively robust, proximal predictors of adolescent substance use. Results from the original project period indicate reductions, on average, in adolescents'substance use following group-based treatment delivered in a community setting;readiness to change predicts substance use over follow-up;and reduction in substance using peers is associated with lower substance use. To follow-up on these findings, 200 adolescents (and their parent) will be recruited from community-based Intensive Outpatient Treatment (IOP) for substance use to participate in a longitudinal study examining social influences (i.e., group-based treatment, peer network, family environment) associated with treatment outcome. Adolescents complete assessments at baseline (treatment entry), 6-, and 12-months covering substance use, personal social network, and psychiatric status. Adolescents also complete monthly follow-ups to track changes in their social network, and new to the continuation, complete ratings after each IOP session to examine associations between group-based treatment (e.g., session """"""""norm"""""""" regarding abstinence) and readiness to change substance use. Parents complete assessments at baseline (treatment entry), 6-, and 12-months.
Study aims are to: (1) track changes in adolescent's readiness to change substance use, a sensitive and proximal predictor of substance use behavior, during and after IOP treatment to identify common group-based treatment factors associated with adolescents'readiness to change and substance use;(2) examine peer selection and peer influence as mechanisms underlying changes in adolescents'substance use;and (3) identify family environment characteristics that facilitate or impede reductions in adolescents'substance use. These study aims will provide important new longitudinal data relevant to the ecologically valid study of short-term outcomes of group-based treatment for adolescents, and social network influences on adolescents'treatment outcomes. Study findings will be used to develop socially- based interventions that promote healthy peer and family relations in treated adolescents.

Public Health Relevance

Social influences, such as participation in group-based treatment for substance abuse, peer social network, and family environment, are relatively robust predictors of adolescent substance abuse treatment outcome. However, little is known regarding the association between common therapeutic factors in group-based treatment (e.g., group norm regarding abstinence) and treatment outcome, as well as how an adolescent's social network composition and structure are related to treatment outcome. This continuation project addresses these gaps in knowledge using intensive data collection in a naturalistic follow-up design to examine social influences on treated adolescent's substance use. Study results have potentially important implications for guiding the development of social network interventions for youth to enhance and maintain treatment gains.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-EE (02))
Program Officer
Lowman, Cherry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Schools of Medicine
United States
Zip Code
Chung, Tammy; Maisto, Stephen A (2016) Time-varying associations between confidence and motivation to abstain from marijuana during treatment among adolescents. Addict Behav 57:62-8
Cornelius, Jack R; Chung, Tammy; Douaihy, Antoine B et al. (2016) Mirtazapine in comorbid major depression and an alcohol use disorder: A double-blind placebo-controlled pilot trial. Psychiatry Res 242:326-30
Seguin, Diane; Shams, Soaleha; Gerlai, Robert (2016) Behavioral Responses to Novelty or to a Predator Stimulus Are Not Altered in Adult Zebrafish by Early Embryonic Alcohol Exposure. Alcohol Clin Exp Res 40:2667-2675
Tran, S; Facciol, A; Gerlai, R (2016) The Zebrafish, a Novel Model Organism for Screening Compounds Affecting Acute and Chronic Ethanol-Induced Effects. Int Rev Neurobiol 126:467-84
Li, James J; Chung, Tammy A; Vanyukov, Michael M et al. (2015) A Hierarchical Factor Model of Executive Functions in Adolescents: Evidence of Gene-Environment Interplay. J Int Neuropsychol Soc 21:62-73
Gerlai, Robert (2015) Embryonic alcohol exposure: Towards the development of a zebrafish model of fetal alcohol spectrum disorders. Dev Psychobiol 57:787-98
Creswell, Kasey G; Chung, Tammy; Clark, Duncan B et al. (2015) Solitary cannabis use in adolescence as a correlate and predictor of cannabis problems. Drug Alcohol Depend 156:120-5
Nowicki, Magda; Tran, Steven; Chatterjee, Diptendu et al. (2015) Inhibition of phosphorylated tyrosine hydroxylase attenuates ethanol-induced hyperactivity in adult zebrafish (Danio rerio). Pharmacol Biochem Behav 138:32-9
Fernandes, Yohaan; Rampersad, Mindy; Gerlai, Robert (2015) Embryonic alcohol exposure impairs the dopaminergic system and social behavioral responses in adult zebrafish. Int J Neuropsychopharmacol 18:
Chung, Tammy; Sealy, Lauren; Abraham, Margaret et al. (2015) Personal Network Characteristics of Youth in Substance Use Treatment: Motivation for and Perceived Difficulty of Positive Network Change. Subst Abus 36:380-8

Showing the most recent 10 out of 49 publications