The proposed project studies the etiology, course, and consequences of substance use and substance disorders from a developmental perspective in a high risk sample. In so doing, it addresses a centrally importani question in substance use research-namely, what are the etiological pathways by which risk is transmitted across multiple generations? We predict heterogeneity in trajectories of substance use outcomes among children o alcoholics and controls, identify mediating mechanisms underlying familial alcoholism risk, andexamine emergin, risk in the next generation using a multi-method prospective study. To achieve these aims, we capitalize on a unique multigenerational high risk samplethat spans the ages from 'substance use initiation to the developmentof substance use disorders and adult """"""""maturing out,"""""""" and for whomdata (have already been collected from three generations (G1-G3). The sample includes alcoholicmothers and fathers whose alcoholism and otherdisorderswere directly ascertained. Beginning in adolescence(M=12.7 years), G2s and) their parents had 3 annual assessments.Further follow-ups (addingfull biologicalsiblings andpeerinformants) were) !done in late adolescence (Wave 4) and early adulthood (Wave 5). Wave 5 also added a baseline multimethodj [assessment of the G3 children (mean age=7.4). At the proposed follow-up, computer-assisted interviews will be conducted with G2adults, their G3adolescent] children, and the G3 adolescent's otherparent. Otherinformant data (peers for adults andteachers for adolescents) (along with school records data will be collected by mail. G3 adolescents will also perform standardized tasks assessing executive and motivational regulatory processes. A short-term 18-month longitudinal design allow; respective prediction of G3 adolescent substance use from existing baseline data as well as the newly.proposed assessments. The findings are particularly important for prevention because they focus on a high risk group,they track the natural history of substance use from its precursors to clinically important end points, they include 'Otentially modifiable factors, and they examine the transmission of risk across three generations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA016213-18
Application #
7564108
Study Section
Special Emphasis Panel (ZRG1-RPHB-H (90))
Program Officer
Shirley, Mariela
Project Start
1987-09-30
Project End
2011-01-31
Budget Start
2009-02-01
Budget End
2010-01-31
Support Year
18
Fiscal Year
2009
Total Cost
$626,753
Indirect Cost
Name
Arizona State University-Tempe Campus
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
943360412
City
Tempe
State
AZ
Country
United States
Zip Code
85287
Rogers, Adam A; Elam, Kit K; Chassin, Laurie et al. (2018) Proximal and Distal Effects of Sensation Seeking and Parenting Environments on Alcohol Use Trajectories from Early Adolescence to Early Adulthood. J Youth Adolesc 47:2206-2219
Wang, Frances L; Chassin, Laurie (2018) Negative Urgency Mediates the Relation between Genetically-Influenced Serotonin Functioning and Alcohol Problems. Clin Psychol Sci 6:106-122
Hill, Melanie; Sternberg, Ariel; Suk, Hye Won et al. (2018) The intergenerational transmission of cannabis use: Associations between parental history of cannabis use and cannabis use disorder, low positive parenting, and offspring cannabis use. Psychol Addict Behav 32:93-103
Elam, Kit K; Chassin, Laurie; Pandika, Danielle (2018) Polygenic risk, family cohesion, and adolescent aggression in Mexican American and European American families: Developmental pathways to alcohol use. Dev Psychopathol 30:1715-1728
Rothenberg, W Andrew; Hussong, Andrea M; Chassin, Laurie (2018) Intergenerational continuity in high-conflict family environments: Investigating a mediating depressive pathway. Dev Psychol 54:385-396
Sternberg, Ariel; Pandika, Danielle; Elam, Kit K et al. (2018) The relation of parent alcohol disorder to young adult drinking outcomes mediated by parenting: Effects of developmentally limited versus persistent parent alcohol disorder. Drug Alcohol Depend 188:224-231
Rothenberg, William A; Hussong, Andrea M; Chassin, Laurie (2017) Modeling Trajectories of Adolescent-Perceived Family Conflict: Effects of Marital Dissatisfaction and Parental Alcoholism. J Res Adolesc 27:105-121
Jensen, Michaeline; Chassin, Laurie; Gonzales, Nancy A (2017) Neighborhood Moderation of Sensation Seeking Effects on Adolescent Substance Use Initiation. J Youth Adolesc 46:1953-1967
Bountress, Kaitlin; Chassin, Laurie; Lemery-Chalfant, Kathryn (2017) Parent and peer influences on emerging adult substance use disorder: A genetically informed study. Dev Psychopathol 29:121-142
Burns, Alison R; Hussong, Andrea M; Solis, Jessica M et al. (2017) Examining Cohort Effects in Developmental Trajectories of Substance Use. Int J Behav Dev 41:621-631

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