There are four intersecting epidemics among pregnant women in South Africa: hazardous alcohol use (30%), HIV (27%), TB (60% of HIV+), and malnutrition (24% of infants). Unless the prevention programs for these epidemics are horizontally integrated, there will never be adequate resources to address these challenges and stigma will dramatically reduce program utilization. Furthermore, while clinics are the typical sites for treating each of these health problems, this proposal will examine a home-visiting prevention program delivered by neighborhood Mentor Mothers (MM) as an alternative to clinic-based interventions to reduce the consequences of hazardous alcohol use, HIV, TB, and poor nutrition. A two phase project is proposed. In Phase 1, we will prepare and finalize the support materials, personnel, procedures, and training for the implementation of a randomized controlled trial (RCT). In Phase 2, we will conduct a RCT evaluating the MM home visiting program, Philani Intervention Project (PIP), on maternal and child outcomes over 18 months. All Mothers at Risk in 20 neighborhoods will be identified (N=600) and randomly assigned by geographic neighborhood to either:1) standard care (SC), mothers and infants with access to clinic-based health care and educational materials;or 2) the PIP. The PIP will encourage mothers to care for their own health, parent well, maintain their mental health, and, if the mother is living with HIV (HIV+ MAR), reduce HIV transmission and/or reduce alcohol use and abuse. The impact of the intervention on a comprehensive composite outcome, the mediating, and background predictors of healthy family routines will be monitored during pregnancy, at the child's birth, and 6 and 18 months later. The results begin to inform the optimal delivery strategy for next generation of preventive interventions in order to be feasible and sustainable for broad dissemination immediately following an efficacy trial.The health and well-being of South Africa's children depends on effectively intervening with the intersecting epidemics of alcohol, HIV,TB, and child malnutrition. South Africa (SA) is distinguished by having both the highest number of persons living with HIV (PLH) (5 million PLH;40% of pregnant women are HIV+) as well as the highest documented rate of children with fetal alcohol syndrome (FAS;6.5% at first grade) (Viljoen et al., 2005). Concurrently, 6% of children die by first grade, and 8.5% of children are malnourished. Alcohol abuse, in addition to its direct effect on children, is consistently related to parents'premature death and child abuse (Frontline, 2006). While clinics are the typical sites for treating each of these health problems, this proposal will examine a home-visiting model as an alternative to clinic-based interventions. Positive results could lead to large scale implementation in South Africa.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA017104-05
Application #
8097406
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Bryant, Kendall
Project Start
2007-09-30
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2011
Total Cost
$675,538
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Tsai, Alexander C; Tomlinson, Mark; Comulada, W Scott et al. (2016) Food insufficiency, depression, and the modifying role of social support: Evidence from a population-based, prospective cohort of pregnant women in peri-urban South Africa. Soc Sci Med 151:69-77
Tomlinson, Mark; Rotheram-Borus, Mary Jane; le Roux, Ingrid M et al. (2016) Thirty-Six-Month Outcomes of a Generalist Paraprofessional Perinatal Home Visiting Intervention in South Africa on Maternal Health and Child Health and Development. Prev Sci 17:937-948
Tsai, Alexander C; Tomlinson, Mark; Comulada, W Scott et al. (2016) Intimate Partner Violence and Depression Symptom Severity among South African Women during Pregnancy and Postpartum: Population-Based Prospective Cohort Study. PLoS Med 13:e1001943
Worthman, Carol M; Tomlinson, Mark; Rotheram-Borus, Mary Jane (2016) When can parents most influence their child's development? Expert knowledge and perceived local realities. Soc Sci Med 154:62-9
Rotheram-Borus, Mary Jane; Tomlinson, Mark; Scheffler, Aaron et al. (2016) Adjustment of a Population of South African Children of Mothers Living With/and Without HIV Through Three Years Post-Birth. AIDS Behav :
Tomlinson, Mark; Rotheram-Borus, Mary Jane; Harwood, Jessica et al. (2015) Community health workers can improve child growth of antenatally-depressed, South African mothers: a cluster randomized controlled trial. BMC Psychiatry 15:225
Rotheram-Borus, Mary Jane; Tomlinson, Mark; Scheffler, Aaron et al. (2015) Re-engagement in HIV care among mothers living with HIV in South Africa over 36 months post-birth. AIDS 29:2361-2
Rotheram-Borus, Mary Jane; Tomlinson, Mark; Le Roux, Ingrid et al. (2015) Alcohol Use, Partner Violence, and Depression: A Cluster Randomized Controlled Trial Among Urban South African Mothers Over 3 Years. Am J Prev Med 49:715-25
le Roux, Karl; le Roux, Ingrid; Mbewu, Nokwanele et al. (2015) The Role of Community Health Workers in the Re-Engineering of Primary Health Care in Rural Eastern Cape. S Afr Fam Pract (2004) 57:116-120
O'Connor, Mary J; Rotheram-Borus, Mary Jane; Tomlinson, Mark et al. (2014) Screening for fetal alcohol spectrum disorders by nonmedical community workers. J Popul Ther Clin Pharmacol 21:e442-52

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