In spite of the adoption of many evidence-based behavioral and pharmacological interventions by alcohol treatment providers it is still common for drinking to occur after treatment, frequently at problematic levels. Very little is known, however, about who is most at risk for heavy drinking relapses, under what conditions non- problematic drinking escalates to pre-treatment levels of drinking or, conversely, heavy drinking is reduced after an initial lapse, and when non-problematic drinking resolves without the need for additional intervention efforts. In general, the mechanisms of change following alcohol treatment are not well understood. To address these gaps in understanding, this study will build an empirical knowledge base of predictors of successful alcohol treatment outcomes among individuals who receive alcohol treatment. The achievement of study aims will provide clinicians with both normative-based guidelines to identify """"""""at risk"""""""" individuals during treatment as well as criteria to evaluate the need for additional treatment when post treatment drinking occurs. To develop these guidelines and criteria, integrative data analysis of factors influencing alcohol clinical course among more than 4,000 individuals (n = 4,415) who participated in four publicly funded alcohol treatment studies will be conducted. In order to characterize individual drinking norms this study will consider the complexities of alcohol clinical course by drawing on a dynamic theoretical model of relapse that emphasizes the interaction between predispositions and risk factors in the prediction of alcohol clinical course.
The first aim of this research is to examine individual patterns of drinking and the probabilities of lapsing at various time points during and following treatment, as well as the probabilities of transitioning from a lapse to relapse. Using these probabilities of drinking as the basis for defining unsuccessful and successful treatment outcomes, this research aims to examine the degree to which individual characteristics and treatment factors interact with individual behaviors and environmental factors in the prediction of alcohol treatment outcomes. The results from this study will be directly applicable to clinical practice by providing guidance on the individual characteristics, precipitating events, and treatment modifiable factors that are associated with changes in drinking patterns during treatment and one year following treatment. These data will allow providers to predict client outcomes during and after treatment and will offer practical strategies regarding steps that could reduce the likelihood of a return to heavy drinking. The results will also help clinicians identify those individual characteristics and environmental factors that predict a higher probability of maintaining a low-risk drinking trajectory. Moreover, the probabilities derived from the research can be used for the development of an empirically-based clinical decision making support system. Such a system, unprecedented in the alcohol treatment field, could be widely disseminated to clinicians, program evaluators, and policy makers in order to help improve alcohol treatment decision-making and improve treatment outcomes.

Public Health Relevance

This study seeks to gain a better understanding of alcohol treatment outcomes and predictors of alcohol treatment success. The results will build a scientific knowledge base that will help guide alcohol treatment planning and decision-making among clients, clinicians, program evaluators, and policy makers. Ultimately, this improved planning and decision-making will result in more successful alcohol treatment outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
1R01AA022328-01
Application #
8561848
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Falk, Daniel
Project Start
2013-08-05
Project End
2016-07-31
Budget Start
2013-08-05
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$313,841
Indirect Cost
$105,140
Name
University of New Mexico
Department
Type
Organized Research Units
DUNS #
868853094
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Maisto, Stephen A; Roos, Corey R; Hallgren, Kevin A et al. (2016) Do Alcohol Relapse Episodes During Treatment Predict Long-Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse. Alcohol Clin Exp Res 40:2180-2189
Roos, Corey R; Mann, Karl; Witkiewitz, Katie (2016) Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone. Addict Biol :
Wilson, Adam D; Bravo, Adrian J; Pearson, Matthew R et al. (2016) Finding success in failure: using latent profile analysis to examine heterogeneity in psychosocial functioning among heavy drinkers following treatment. Addiction :
Pearson, Matthew R; Kirouac, Megan; Witkiewitz, Katie (2016) Questioning the validity of the 4+/5+ binge or heavy drinking criterion in college and clinical populations. Addiction 111:1720-6
Witkiewitz, Katie; Hallgren, Kevin A; O'Sickey, Anthony J et al. (2016) Reproducibility and differential item functioning of the alcohol dependence syndrome construct across four alcohol treatment studies: An integrative data analysis. Drug Alcohol Depend 158:86-93
Hallgren, Kevin A; Atkins, David C; Witkiewitz, Katie (2016) Aggregating and Analyzing Daily Drinking Data in Clinical Trials: A Comparison of Type I Errors, Power, and Bias. J Stud Alcohol Drugs 77:986-991
Roos, Corey R; Witkiewitz, Katie (2016) Adding tools to the toolbox: The role of coping repertoire in alcohol treatment. J Consult Clin Psychol 84:599-611
Pearson, Matthew R; Kirouac, Megan; Witkiewitz, Katie (2016) We still question the utility and validity of the binge/heavy drinking criterion. Addiction 111:1733-4
Maisto, Stephen A; Witkiewitz, Katie; Moskal, Dezarie et al. (2016) Is the Construct of Relapse Heuristic, and Does It Advance Alcohol Use Disorder Clinical Practice? J Stud Alcohol Drugs 77:849-858
Kirouac, Megan; Witkiewitz, Katie; Donovan, Dennis M (2016) Client Evaluation of Treatment for Alcohol Use Disorder in COMBINE. J Subst Abuse Treat 67:38-43

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