Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG007218-04A1S1
Application #
3118330
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1987-05-01
Project End
1991-06-30
Budget Start
1991-01-16
Budget End
1991-06-30
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Etzler, Julie C; Bollo, Mariana; Holstein, Deborah et al. (2017) Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation. Arch Biochem Biophys 613:61-68
Lopez-Cruzan, M; Sharma, R; Tiwari, M et al. (2016) Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment. Cell Death Discov 2:
Talley Watts, Lora; Zheng, Wei; Garling, R Justin et al. (2015) Rose Bengal Photothrombosis by Confocal Optical Imaging In Vivo: A Model of Single Vessel Stroke. J Vis Exp :e52794
Bierbower, Sonya M; Choveau, Frank S; Lechleiter, James D et al. (2015) Augmentation of M-type (KCNQ) potassium channels as a novel strategy to reduce stroke-induced brain injury. J Neurosci 35:2101-11
Sharma, Ramaswamy; Callaway, Danielle; Vanegas, Difernando et al. (2014) Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts. PLoS One 9:e93696
Lopez-Cruzan, Marisa; Herman, Brian (2013) Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species. Biogerontology 14:121-30
Tiwari, Meenakshi; Herman, Brian; Morgan, William W (2011) A knockout of the caspase 2 gene produces increased resistance of the nigrostriatal dopaminergic pathway to MPTP-induced toxicity. Exp Neurol 229:421-8
Ramanujan, V K; Jo, J A; Cantu, G et al. (2008) Spatially resolved fluorescence lifetime mapping of enzyme kinetics in living cells. J Microsc 230:329-38
Kalkonde, Yogeshwar V; Morgan, William W; Sigala, Jose et al. (2007) Chemokines in the MPTP model of Parkinson's disease: absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration. Brain Res 1128:1-11
Ramanujan, V Krishnan; Herman, Brian A (2007) Aging process modulates nonlinear dynamics in liver cell metabolism. J Biol Chem 282:19217-26

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