Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG008084-08
Application #
2050031
Study Section
Neurology C Study Section (NEUC)
Project Start
1989-02-01
Project End
1997-01-31
Budget Start
1996-02-20
Budget End
1997-01-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Biology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Geller, L N; Potter, H (1999) Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease. Neurobiol Dis 6:167-79
DeFranco, C; Chicurel, M E; Potter, H (1998) A general RNA-binding protein complex that includes the cytoskeleton-associated protein MAP 1A. Mol Biol Cell 9:1695-708
Kayyali, U S; Zhang, W; Yee, A G et al. (1997) Cytoskeletal changes in the brains of mice lacking calcineurin A alpha. J Neurochem 68:1668-78
Li, J; Xu, M; Zhou, H et al. (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 90:917-27
Li, J; Ma, J; Potter, H (1995) Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3. Proc Natl Acad Sci U S A 92:12180-4
Potter, H (1993) Application of electroporation in recombinant DNA technology. Methods Enzymol 217:461-78
Nelson, R B; Siman, R; Iqbal, M A et al. (1993) Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein. J Neurochem 61:567-77
Chicurel, M E; Terrian, D M; Potter, H (1993) mRNA at the synapse: analysis of a synaptosomal preparation enriched in hippocampal dendritic spines. J Neurosci 13:4054-63
Potter, H; Nelson, R B; Das, S et al. (1992) The involvement of proteases, protease inhibitors, and an acute phase response in Alzheimer's disease. Ann N Y Acad Sci 674:161-73
Abraham, C R; Driscoll, J; Potter, H et al. (1991) A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein. Biochem Biophys Res Commun 174:790-6