This project will identify mechanisms underlying age-related changes in cognition. Two general hypotheses as to the specific nature of these mechanisms will guide the research. Under one hypothesis, inhibitory processes become less effective in older adults, while under the other, age weakens the strength of connections between the units of memory, so that activity transmitted from one unit to another declines with age. Empirical support for one or the other hypothesis that will emerge from the proposed research promises to have a major impact on the field. By examining a series of phenomena that have rarely if ever been examined in older adults, e.g., repetition blindness, illusory conjunctions, effects of delayed and amplified auditory feedback and the relative ability to perceive vs. produce speech, the project promises to fill several gaps in our knowledge. Moreover, the project focuses on tasks and phenomena where older adults are predicted to exhibit superior performance to younger adults, unlike previous work where declines in the abilities of older adults have been the main focus. The project also carries theoretical and practical implications for many areas of cognitive psychology, including seemingly unrelated areas such as word retrieval failures, and the etiology of stuttering. Finally, the project will develop a testable and well specified model of aging and cognition that is computational in nature. Five sets of studies are proposed. The first two sets compare the perceptual errors of young and older subjects in detecting rapidly presented letters and acoustically presented words. A third set examines the effects of aging on experimentally induced errors in production. A fourth set compares the ability to comprehend vs. produce speech in young and older adults to determine why production processes tend to become impaired with aging, whereas comprehension processes remain relatively intact. The fifth set of studies will develop computer simulations of how cognitive processes change with age.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG009755-01
Application #
3121648
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Project Start
1991-05-06
Project End
1994-04-30
Budget Start
1991-05-06
Budget End
1992-04-30
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
MacKay, Donald G; James, Lori E; Hadley, Christopher B et al. (2011) Speech errors of amnesic H.M.: unlike everyday slips-of-the-tongue. Cortex 47:377-408
MacKay, Donald G; James, Lori E (2009) Visual cognition in amnesic H.M.: selective deficits on the What's-Wrong-Here and Hidden-Figure tasks. J Clin Exp Neuropsychol 31:769-89
MacKay, Donald G; James, Lori E; Hadley, Christopher B (2008) Amnesic H.M.'s performance on the language competence test: parallel deficits in memory and sentence production. J Clin Exp Neuropsychol 30:280-300
MacKay, Donald G; James, Lori E (2004) Sequencing, speech production, and selective effects of aging on phonological and morphological speech errors. Psychol Aging 19:93-107
MacKay, Donald G; Shafto, Meredith; Taylor, Jennifer K et al. (2004) Relations between emotion, memory, and attention: evidence from taboo stroop, lexical decision, and immediate memory tasks. Mem Cognit 32:474-88
James, L E; MacKay, D G (2001) H.M., word knowledge, and aging: support for a new theory of long-term retrograde amnesia. Psychol Sci 12:485-92
MacKay, D G (2001) A tale of two paradigms or metatheoretical approaches to cognitive neuropsychology: did Schmolck, Stefanacci, and Squire (2000) show that hippocampal lesions only impair memory, whereas adjacent (extrahippocampal) lesions impair detection and explanation Brain Lang 78:265-72; discussion 273-5
MacKay, D G; Stewart, R; Burke, D M (1998) H.M. revisited: relations between language comprehension, memory, and the hippocampal system. J Cogn Neurosci 10:377-94
MacKay, D G; Abrams, L; Pedroza, M J et al. (1996) Cross-language facilitation, semantic blindness, and the relation between language and memory: a reply to Altarriba and Soltano. Mem Cognit 24:712-8
MacKay, D G; Miller, M D; Schuster, S P (1994) Repetition blindness and aging: evidence for a binding deficit involving a single, theoretically specified connection. Psychol Aging 9:251-8