Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG009900-06
Application #
2051156
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1991-05-03
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Buckley, Peter T; Khaladkar, Mugdha; Kim, Junhyong et al. (2014) Cytoplasmic intron retention, function, splicing, and the sentinel RNA hypothesis. Wiley Interdiscip Rev RNA 5:223-30
Bartfai, Tamas; Buckley, Peter T; Eberwine, James (2012) Drug targets: single-cell transcriptomics hastens unbiased discovery. Trends Pharmacol Sci 33:9-16
Buckley, Peter T; Lee, Miler T; Sul, Jai-Yoon et al. (2011) Cytoplasmic intron sequence-retaining transcripts can be dendritically targeted via ID element retrotransposons. Neuron 69:877-84
Ross, John R; Porter, Brenda E; Buckley, Peter T et al. (2011) mRNA for the EAAC1 subtype of glutamate transporter is present in neuronal dendrites in vitro and dramatically increases in vivo after a seizure. Neurochem Int 58:366-75
Kim, Junhyong; Eberwine, James (2010) RNA: state memory and mediator of cellular phenotype. Trends Cell Biol 20:311-8
Sanchez-Alavez, Manuel; Tabarean, Iustin V; Osborn, Olivia et al. (2010) Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons. Diabetes 59:43-50
Bell, Thomas J; Miyashiro, Kevin Y; Sul, Jai-Yoon et al. (2010) Intron retention facilitates splice variant diversity in calcium-activated big potassium channel populations. Proc Natl Acad Sci U S A 107:21152-7
Bell, Thomas J; Miyashiro, Kevin Y; Sul, Jai-Yoon et al. (2008) Cytoplasmic BK(Ca) channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons. Proc Natl Acad Sci U S A 105:1901-6
Wu, Chia-wen K; Zeng, Fanyi; Eberwine, James (2007) mRNA transport to and translation in neuronal dendrites. Anal Bioanal Chem 387:59-62
Zielinski, Jennifer; Kilk, Kalle; Peritz, Tiina et al. (2006) In vivo identification of ribonucleoprotein-RNA interactions. Proc Natl Acad Sci U S A 103:1557-62

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