Cognitive impairment associated with diseases of aging is a major public health problem. Neuropsychological tests of cognitive abilities have long been used to measure changes in cognition related to diseases like Alzheimer's disease. The use of cognitive tests is complicated by influences on test performance of variables that are not related to disease and can result in measurement bias in ethnically and demographically diverse populations. The challenge is to measure disease effects in a way that is unbiased by extraneous influences associated with ethnicity and demographic heterogeneity. This is a competing renewal application for a project initiated in 1992 that has an overarching goal of developing and validating psychometrically sophisticated neuropsychological tests that can be used effectively in English and Spanish speaking older individuals. The Spanish and English Neuropsychological Assessment Scales (SENAS) have been developed in this project to meet these goals using advanced psychometric methods. The goals for the next cycle will be to: 1) independently model disease effects and effects of ethnicity and associated variables on cognition using cross-sectional and longitudinal data, 2) further validate the SENAS as a measure of cognitive impairment and decline that can be used effectively with English and Spanish speakers from different ethnic backgrounds, and 3) develop an item bank for SENAS scales that can be incorporated into a computerized adaptive testing format using emerging technology. The following specific aims will be addressed: 1) Characterize the item-level and scale- level effects of ethnicity and associated variables and proxies for disease status on SENAS measures, 2) Evaluate the relative sensitivity of SENAS measures to change in global and regional structural MRI variables in different language and ethnic groups, 3) Develop a model to explain the contributions of disease effects and ethnicity and related variables to baseline cognition and longitudinal change in cognition, and 4) Develop and validate computerized adaptive testing (CAT) methods for SENAS scales that will maximize efficiency and minimize burden associated with cognitive testing, and promote standardization and availability of SENAS methods.
This project will examine multiple influences on cognitive function in ethnically and demographically diverse older people demographically. It will provide information that will increase understanding of cognitive decline in older people and will improve our ability to measure these changes.
|Melrose, Rebecca J; Brewster, Paul; Marquine, María J et al. (2015) Early life development in a multiethnic sample and the relation to late life cognition. J Gerontol B Psychol Sci Soc Sci 70:519-31|
|Brewster, Paul W H; Melrose, Rebecca J; Marquine, María J et al. (2014) Life experience and demographic influences on cognitive function in older adults. Neuropsychology 28:846-58|
|Ober, Beth A; Shenaut, Gregory K (2014) Repetition priming of words and nonwords in Alzheimer's disease and normal aging. Neuropsychology 28:973-83|
|Maillard, Pauline; Fletcher, Evan; Lockhart, Samuel N et al. (2014) White matter hyperintensities and their penumbra lie along a continuum of injury in the aging brain. Stroke 45:1721-6|
|Rog, Lauren A; Park, Lovingly Quitania; Harvey, Danielle J et al. (2014) The independent contributions of cognitive impairment and neuropsychiatric symptoms to everyday function in older adults. Clin Neuropsychol 28:215-36|
|Maillard, P; Carmichael, O; Harvey, D et al. (2013) FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities. AJNR Am J Neuroradiol 34:54-61|
|Farias, Sarah Tomaszewski; Park, Lovingly Quitania; Harvey, Danielle J et al. (2013) Everyday cognition in older adults: associations with neuropsychological performance and structural brain imaging. J Int Neuropsychol Soc 19:430-41|
|Carmichael, Owen; Mungas, Dan; Beckett, Laurel et al. (2012) MRI predictors of cognitive change in a diverse and carefully characterized elderly population. Neurobiol Aging 33:83-95|
|Mungas, Dan; Widaman, Keith F; Reed, Bruce R et al. (2011) Measurement invariance of neuropsychological tests in diverse older persons. Neuropsychology 25:260-9|
|Maillard, Pauline; Fletcher, Evan; Harvey, Danielle et al. (2011) White matter hyperintensity penumbra. Stroke 42:1917-22|
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