Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011604-02
Application #
2052828
Study Section
Nutrition Study Section (NTN)
Project Start
1995-07-10
Project End
1998-06-30
Budget Start
1996-07-12
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Veterinary Sciences
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Lushaj, Entela Bua; Johnson, Jody K; McKenzie, Debbie et al. (2008) Sarcopenia accelerates at advanced ages in Fisher 344xBrown Norway rats. J Gerontol A Biol Sci Med Sci 63:921-7
Herbst, Allen; Pak, Jeong W; McKenzie, Debbie et al. (2007) Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss. J Gerontol A Biol Sci Med Sci 62:235-45
Gokey, Nolan G; Cao, Zhengjin; Pak, Jeong W et al. (2004) Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys. Aging Cell 3:319-26
Bua, Entela A; McKiernan, Susan H; Wanagat, Jonathan et al. (2002) Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia. J Appl Physiol 92:2617-24
Aiken, Judd; Bua, Entela; Cao, Zhengjin et al. (2002) Mitochondrial DNA deletion mutations and sarcopenia. Ann N Y Acad Sci 959:412-23
Cao, Z; Wanagat, J; McKiernan, S H et al. (2001) Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res 29:4502-8
Wanagat, J; Cao, Z; Pathare, P et al. (2001) Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J 15:322-32
Lopez, M E; Van Zeeland, N L; Dahl, D B et al. (2000) Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res 452:123-38
Schwarze, S R; Weindruch, R; Aiken, J M (1998) Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med 25:740-7
Schwarze, S R; Weindruch, R; Aiken, J M (1998) Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutat Res 382:99-107

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