This is a continuation of a prospective cohort study of ovarian aging. The study focuses on hormone dynamics and associated symptoms as premenopausalwomen enter and move through stages in the transition to menopause.
The specific aims are to: 1)) Compare hormone levels and longitudinal trends between African American and Caucasian women;2) Identify how within-woman trends of the study hormones (estradiol, FSH, LH, Inhibin B, DHEAS, and testosterone) and cofactors such as BMI, race, age, symptoms, et al predict the progression through the transition;3) Identify associations of hormonedynamics with physical and behavioral symptoms that occur with ovarian aging and identify racial differences in these factors;4) Identify associations of genetic polymorphisms with levels and longitudinal trends and with menopausal symptoms. Hormone evaluations and a battery of physical and behavioral assessmentsare collected annually on days 1-6 of two consecutive menstrual cycles or 1 month apart in non-cycling women. Continuation of this cohort study will provide new information on hormone dynamics and their influences on menopausal symptoms through the full menopausal transition.- ???? ......... More than 80% of U.S. women experience physical or behavioral symptoms around menopause,with varying degrees of severity and disruption in their functioning, and many of these women seek medical relief for distressing symptoms. The lack of understanding of the contributors to these symptoms and their associations with hormonal factors of ovarian aging is a significant health care problem. Increased understanding of the changes associated with reproductive aging and whether there are racial differences in these changes will lead to better preventive and therapeutic strategies to reduce the short and long term morbidity of women's mid-life and postmenopausalyears.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
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Study Section
Epidemiology of Chronic Diseases Study Section (ECD)
Program Officer
Sherman, Sherry
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University of Pennsylvania
Obstetrics & Gynecology
Schools of Medicine
United States
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Freeman, Ellen W; Sammel, Mary D (2016) Anxiety as a risk factor for menopausal hot flashes: evidence from the Penn Ovarian Aging cohort. Menopause 23:942-9
Milman, Lauren W; Sammel, Mary D; Barnhart, Kurt T et al. (2015) Higher serum total testosterone levels correlate with increased risk of depressive symptoms in Caucasian women through the entire menopausal transition. Psychoneuroendocrinology 62:107-13
Freeman, Ellen W; Sammel, Mary D; Gross, Stephanie A et al. (2015) Poor sleep in relation to natural menopause: a population-based 14-year follow-up of midlife women. Menopause 22:719-26
Jiang, Bei; Sammel, Mary D; Freeman, Ellen W et al. (2015) Bayesian estimation of associations between identified longitudinal hormone subgroups and age at final menstrual period. BMC Med Res Methodol 15:106
Butts, Samantha F; Sammel, Mary D; Greer, Christine et al. (2014) Cigarettes, genetic background, and menopausal timing: the presence of single nucleotide polymorphisms in cytochrome P450 genes is associated with increased risk of natural menopause in European-American smokers. Menopause 21:694-701
Freeman, Ellen W; Sammel, Mary D; Sanders, Richard J (2014) Risk of long-term hot flashes after natural menopause: evidence from the Penn Ovarian Aging Study cohort. Menopause 21:924-32
Freeman, Ellen W; Sammel, Mary D; Boorman, David W et al. (2014) Longitudinal pattern of depressive symptoms around natural menopause. JAMA Psychiatry 71:36-43
Senapati, S; Gracia, C R; Freeman, E W et al. (2014) Hormone variations associated with quantitative fat measures in the menopausal transition. Climacteric 17:183-90
Epperson, C Neill; Sammel, Mary D; Freeman, Ellen W (2013) Menopause effects on verbal memory: findings from a longitudinal community cohort. J Clin Endocrinol Metab 98:3829-38
Butts, Samantha F; Freeman, Ellen W; Sammel, Mary D et al. (2012) Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women. J Clin Endocrinol Metab 97:E1032-42

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