The common and modifiable nature of many cardiovascular and metabolic risk factors, especially hypertension, and obesity, makes them excellent targets for prevention of and intervention for cognitive and functional impairment and dementia and mortality. Vascular and metabolic conditions are more common and more likely to be under-diagnosed and untreated in Mexican Americans, leading to more severe disease, poorer survival and greater risk of dementia and cognitive and functional decline. This study will evaluate the long-term effects of metabolic and vascular risk factors on cognition, function and mortality in a 10 year study of 1,789 older Mexican Americans. It will address the role of social and cultural factors in this context. Study results will have implications for prevention of late life impairments that will be applicable beyond this particular ethnic group.
Our aims address two sets of related risk factors: body composition and blood pressure. This project takes advantage of a unique collaboration between investigators at the University of Michigan, School of Public Health, Departments of Epidemiology and Biostatistics and the UC Davis Alzheimer's Center and the Younkin Lab at Mayo Clinic Florida.
AIM 1. Evaluate the effects of change over time in systolic and diastolic blood pressure, peripheral vascular disease and within-person blood pressure variability on study outcomes.
AIM 2. Evaluate the effects of body composition and changes in body composition on study outcomes.
AIM 3. Evaluate biological mediators of the association between vascular and metabolic conditions and study outcomes.
AIM 4. Evaluate the association of blood pressure and body composition to MRI-measured global and regional atrophy, abnormal white matter (WMH) signals and infarcts as links to dementia and cognitive and functional impairment.
AIM 5. Evaluate social and cultural factors and how they are biologically mediated in relation to study outcomes.
This study will evaluate the long-term effects of obesity and hypertension cognition, function and mortality in a 10 year study of 1,789 older Mexican Americans. It will address the role of social and cultural factors in this context. Study results will have implications for prevention of late life impairments that will be applicable beyond this particular ethnic group.
|Ward, Julia B; Haan, Mary N; Garcia, Maria E et al. (2016) Intergenerational education mobility and depressive symptoms in a population of Mexican origin. Ann Epidemiol 26:461-6|
|Vajaranant, Thasarat S; Maki, Pauline M; Pasquale, Louis R et al. (2016) Effects of Hormone Therapy on Intraocular Pressure: The Women's Health Initiative-Sight Exam Study. Am J Ophthalmol 165:115-24|
|Garcia, Lorena; Lee, Anne; Zeki Al Hazzouri, Adina et al. (2016) Influence of neighbourhood socioeconomic position on the transition to type II diabetes in older Mexican Americans: the Sacramento Area Longitudinal Study on Aging. BMJ Open 6:e010905|
|Garcia, Maria E; Lee, Anne; Neuhaus, John et al. (2016) Diabetes Mellitus as a Risk Factor for Development of Depressive Symptoms in a Population-Based Cohort of Older Mexican Americans. J Am Geriatr Soc 64:619-24|
|Chatterjee, Saion; Peters, Sanne A E; Woodward, Mark et al. (2016) Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia. Diabetes Care 39:300-7|
|Carnahan, Jennifer L; Unroe, Kathleen T; Torke, Alexia M (2016) Hospital Readmission Penalties: Coming Soon to a Nursing Home Near You! J Am Geriatr Soc 64:614-8|
|Torres, Jacqueline M; Lee, Anne; GonzÃ¡lez, Hector M et al. (2016) A longitudinal analysis of cross-border ties and depression for Latino adults. Soc Sci Med 160:111-9|
|Haan, Mary N; Lee, Anne; Odden, Michelle C et al. (2016) Gender Differences in the Combined Effects of Cardiovascular Disease and Osteoarthritis on Progression to Functional Impairment in Older Mexican Americans. J Gerontol A Biol Sci Med Sci 71:1089-95|
|Mayeda, Elizabeth R; Haan, Mary N; Yaffe, Kristine et al. (2015) Does type 2 diabetes increase rate of cognitive decline in older Mexican Americans? Alzheimer Dis Assoc Disord 29:206-12|
|Garcia, Lorena; Lee, Anne; Zeki Al Hazzouri, Adina et al. (2015) The Impact of Neighborhood Socioeconomic Position on Prevalence of Diabetes and Prediabetes in Older Latinos: The Sacramento Area Latino Study on Aging. Hisp Health Care Int 13:77-85|
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