Aging cohorts suffer from informative censoring due to competing risks of death, selective non- mortality attrition, as well as time dependent changes in exposure. Multiple interdependent exposures and outcomes are little studied in relation to health disparities. Death is undeniably a major force shaping patterns of change in risk factors and disease risk in older populations. Increasing interactions of multiple conditions over time complicate analysis. These processes differentially affect race/ethnic health disparities because, among disadvantaged populations, exposures to risk factors typically are higher, start earlier in life, are more sustained and more often under/untreated. Race/ethnic comparisons of risk that do not account for competing risk are likely to incorrectly estimate the impact of treatment or prevention on disease. Mexican Americans have higher prevalence of diabetes, obesity, and metabolic syndrome at younger ages compared to non-Hispanic whites (NHW). Most older people in this high risk ethnic group have experienced lifelong poverty, low education, and hazardous occupations. As such, compared to non-Hispanic whites, they are at higher risk for stroke, dementia, and cognitive and functional impairments and have poorer survival so competing risk of death is likely to be a major issue in analysis. Policy and intervention. Our study has implications for treatment and prevention policies for health and social services. Success in delaying death may mean survivors with more severe disease who are at higher risk for multiple impairments that especially impact disadvantaged Americans. Increases in obesity, metabolic syndrome, and type 2 diabetes in younger people are projected to lead to future increases in late life impairment The Sacramento Area Latino Study on Aging was followed from 1998 to the present. This competing renewal application focuses on analysis of existing data collected annually and semi-annually since 1998 and continuation of 13 years of mortality follow-up for another 3 years.
Study Aims are:
AIM 1. 0.Type 2 diabetes is simultaneously associated with increased risk of cognitive and functional decline, stroke, dementia and death. Statistical methods that account for competing risk of death will produce lower and less biased estimates of these associations than in traditional models.
AIM 2. 0.Hypertension is simultaneously associated with the increased risk of cognitive and functional decline, stroke, dementia and death. The association of HTN with nonfatal outcomes is influenced by competing risk (CRisk) of death. Statistical methods that account for competing risk of death will produce lower and less biased estimates of these associations than traditional models provide.
AIM 3. 0: Comorbidity is cumulative over time and is simultaneously associated with the multiple outcomes of greater cognitive and functional decline, and dementia and death. Simultaneous joint modeling of time dependent comorbidities with multiple outcomes accounting for informative censoring will provide important information about the underlying syndrome comprised by these conditions and improve statistical efficiency.
This study will examine the effects of high mortality rates on the association between type 2 diabetes or hypertension on cognitive decline, stroke, dementia and functional impairments in aging Mexican Americans.
|Ward, Julia B; Robinson, Whitney R; Pence, Brian W et al. (2018) Educational Mobility Across Generations and Depressive Symptoms Over 10 Years Among US Latinos. Am J Epidemiol :|
|Paul, Kimberly C; Ling, Chenxiao; Lee, Anne et al. (2018) Cognitive decline, mortality, and organophosphorus exposure in aging Mexican Americans. Environ Res 160:132-139|
|Torres, Jacqueline M; Epel, Elissa S; To, Tu My et al. (2018) Cross-border ties, nativity, and inflammatory markers in a population-based prospective study of Latino adults. Soc Sci Med 211:21-30|
|Mungas, Dan; Early, Dawnté R; Glymour, M Maria et al. (2018) Education, bilingualism, and cognitive trajectories: Sacramento Area Latino Aging Study (SALSA). Neuropsychology 32:77-88|
|Ward, Julia B; Albrecht, Sandra S; Robinson, Whitney R et al. (2018) Neighborhood language isolation and depressive symptoms among elderly U.S. Latinos. Ann Epidemiol 28:774-782|
|Martin, Chantel L; Haan, Mary N; Fernandez-Rhodes, Lindsay et al. (2018) Association Between Immigration History and Inflammatory Marker Profiles Among Older Adult Mexican Americans. Biodemography Soc Biol 64:30-42|
|Shih, I-Fan; Paul, Kimberly; Haan, Mary et al. (2018) Physical activity modifies the influence of apolipoprotein E ?4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans. Alzheimers Dement 14:1-9|
|Osypuk, Theresa L; Ehntholt, Amy; Moon, J Robin et al. (2017) Neighborhood Differences in Post-Stroke Mortality. Circ Cardiovasc Qual Outcomes 10:|
|Ward, Julia B; Feinstein, Lydia; Vines, Anissa I et al. (2017) Perceived discrimination and depressive symptoms among US Latinos: the modifying role of educational attainment. Ethn Health :1-16|
|Qian, Jing; Wolters, Frank J; Beiser, Alexa et al. (2017) APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Med 14:e1002254|
Showing the most recent 10 out of 118 publications