Abstract

The general hypothesis is that the decrease in muscle mass and function that occurs in elderly individuals can be ameliorated with an appropriate nutritional supplementation. The goal is to develop a scientific basis for a nutritional supplement that will stimulate net muscle anabolism to a greater extent than a comparable amount of their normal diet. These investigators will determine the mixture of a given amount of amino acids that will stimulate muscle protein synthesis. The effect of non-protein energy alone and in conjunction with amino acid intake, will also be evaluated. Studies will be performed in a group of healthy, active elderly subjects and in a separate group of frail elderly subjects. These studies will provide the metabolic basis for the formulation of a nutritional supplement that should optimally stimulate net muscle protein synthesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG015780-03
Application #
6169244
Study Section
Special Emphasis Panel (ZRG4-GRM (01))
Program Officer
Premen, Andre J
Project Start
1998-09-01
Project End
2003-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
3
Fiscal Year
2000
Total Cost
$237,258
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Surgery
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Tuvdendorj, Demidmaa; Chinkes, David L; Zhang, Xiao-Jun et al. (2011) Skeletal muscle is anabolically unresponsive to an amino acid infusion in pediatric burn patients 6 months postinjury. Ann Surg 253:592-7
Highstead, R Grant; Tipton, Kevin D; Creson, Daniel L et al. (2005) Incidence of associated events during the performance of invasive procedures in healthy human volunteers. J Appl Physiol 98:1202-6
Volpi, Elena; Kobayashi, Hisamine; Sheffield-Moore, Melinda et al. (2003) Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 78:250-8
Wolfe, Robert R (2002) Regulation of muscle protein by amino acids. J Nutr 132:3219S-24S
Rasmussen, B B; Wolfe, R R; Volpi, E (2002) Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly. J Nutr Health Aging 6:358-62
Volpi, E; Sheffield-Moore, M; Rasmussen, B B et al. (2001) Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA 286:1206-12
Wolfe, R R (2001) Effects of amino acid intake on anabolic processes. Can J Appl Physiol 26 Suppl:S220-7
Mittendorfer, B; Volpi, E; Wolfe, R R (2001) Whole body and skeletal muscle glutamine metabolism in healthy subjects. Am J Physiol Endocrinol Metab 280:E323-33
Wolfe, R R (2001) Control of muscle protein breakdown: effects of activity and nutritional states. Int J Sport Nutr Exerc Metab 11 Suppl:S164-9
Volpi, E; Rasmussen, B B (2000) Nutrition and muscle protein metabolism in the elderly. Diabetes Nutr Metab 13:99-107

Showing the most recent 10 out of 12 publications