National health surveys have identified that 30 percent of persons aged 45-64 had some functional limitation or disability, and of those, 50 percent of persons identified that the functional limitations have proven to be the best predictor of mortality, hospitalization, and utilization of health care services included supportive services. However, relatively little attention has been directed to understanding the development of functional limitations (which probably begins for many women in mid-life) and their relation to the development of chronic diseases. We propose to continue and expand a study of physical functioning and osteoarthritis in women age-eligible to experience the menopause, begun as a Michigan site-specific study to the Study of Women Across the Nation (SWAN I), the multi-centered, community-based study of women at the mid-life with a focus on menopause. This study will run concurrently with SWAN II. The goals are to describe the natural history of the development of functional limitations in 500 mid-aged African American and Euro American women. The first goal is to characterize with greater specificity the physical functioning status of mid-aged women using both self-reported and performance-based measures of strength, muscle mass, balance/coordination and joint compromise (radiographically-defined arthritis). The second goal is to determine if the onset (incidence) or severity (progression) of limitations of physical functioning in women (aged 42-52 at baseline of SWAN I) is associated with the menopausal transition. The third goal is to relate measures of physical functioning to markers for chronic diseases including cardiovascular disease, diabetes, hypertension and osteoporosis in a longitudinal manner. There is relatively little research about the natural history of functional limitations among women yet, in the ages of 40-55, there are more women with functional limitations and disabilities than men. Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men (NCHS, 1997).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG017104-05
Application #
6745138
Study Section
Special Emphasis Panel (ZRG1-SNEM-1 (03))
Program Officer
Sherman, Sherry
Project Start
2000-05-15
Project End
2006-04-30
Budget Start
2004-06-15
Budget End
2006-04-30
Support Year
5
Fiscal Year
2004
Total Cost
$124,440
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Berent-Spillson, Alison; Marsh, Courtney; Persad, Carol et al. (2017) Metabolic and hormone influences on emotion processing during menopause. Psychoneuroendocrinology 76:218-225
Chandrasekaran, Navasuja; Harlow, Sioban; Moroi, Sayoko et al. (2017) Visual impairment at baseline is associated with future poor physical functioning among middle-aged women: The Study of Women's Health Across the Nation, Michigan Site. Maturitas 96:33-38
Zheng, Huiyong; Harlow, Siobán D; Kravitz, Howard M et al. (2015) Actigraphy-defined measures of sleep and movement across the menstrual cycle in midlife menstruating women: Study of Women's Health Across the Nation Sleep Study. Menopause 22:66-74
Yu, E W; Putman, M S; Derrico, N et al. (2015) Defects in cortical microarchitecture among African-American women with type 2 diabetes. Osteoporos Int 26:673-9
Karvonen-Gutierrez, Carrie A; Harlow, Siobán D; Jacobson, Jon et al. (2014) The relationship between longitudinal serum leptin measures and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women. Ann Rheum Dis 73:883-9
Karvonen-Gutierrez, Carrie A; Harlow, Siobán D; Mancuso, Peter et al. (2013) Association of leptin levels with radiographic knee osteoarthritis among a cohort of midlife women. Arthritis Care Res (Hoboken) 65:936-44
Berent-Spillson, Alison; Persad, Carol C; Love, Tiffany et al. (2012) Hormonal environment affects cognition independent of age during the menopause transition. J Clin Endocrinol Metab 97:E1686-94
Zheng, Huiyong; Sowers, MaryFran; Buysse, Daniel J et al. (2012) Sources of variability in epidemiological studies of sleep using repeated nights of in-home polysomnography: SWAN Sleep Study. J Clin Sleep Med 8:87-96
Sowers, Maryfran R; Randolph, John F; Zheng, Huiyong et al. (2011) Genetic polymorphisms and obesity influence estradiol decline during the menopause. Clin Endocrinol (Oxf) 74:618-23
Tomey, Kristin; Sowers, MaryFran R; Harlow, Sioban et al. (2010) Physical functioning among mid-life women: associations with trajectory of depressive symptoms. Soc Sci Med 71:1259-1267

Showing the most recent 10 out of 26 publications