Abstract

The overall goal of this project is to define the characteristics and neuroanatomical predictors of attention and executive impairments in frontotemporal dementia (FTD). FTD is a neurodegenerative disorder that differentially affects the frontal lobes. Frontally mediated deficits in attention and executive functioning are central features of FTD that have far reaching consequences for behavior, including cognitive rigidity, disinhibition, inability to sustain goal-oriented behavior, and poor functional adaptation in the context of relative preservation of memory, language, and spatial ability. Despite their importance for diagnosis and patient care, these attentional and executive deficits are poorly understood. We will study 75 patients with mild FTD, 75 severity-matched patients with AD, and 100 age-matched controls using cognitive models of attention and executive functioning that enable parsing of attention into several key components associated with anterior and posterior networks.
Specific aims are to evaluate differences between FTD, AD and controls in executive control of attention, test whether specific regions of cerebral atrophy are selectively associated with impairment on attentional tasks, and evaluate the functional significance of attentional and executive deficits in FTD and AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG022983-05
Application #
7473179
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Silverberg, Nina B
Project Start
2004-09-01
Project End
2010-07-31
Budget Start
2008-08-01
Budget End
2010-07-31
Support Year
5
Fiscal Year
2008
Total Cost
$212,238
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Neurology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Sturm, Virginia E; Perry, David C; Wood, Kristie et al. (2017) Prosocial deficits in behavioral variant frontotemporal dementia relate to reward network atrophy. Brain Behav 7:e00807
Perry, David C; Brown, Jesse A; Possin, Katherine L et al. (2017) Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain 140:3329-3345
Perry, David C; Datta, Samir; Sturm, Virginia E et al. (2017) Reward deficits in behavioural variant frontotemporal dementia include insensitivity to negative stimuli. Brain 140:3346-3356
Chiong, Winston; Wood, Kristie A; Beagle, Alexander J et al. (2016) Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia. Brain 139:578-87
Kalapatapu, Raj K; Delucchi, Kevin L; Wang, Sophia et al. (2016) Substance use history in behavioral-variant frontotemporal dementia versus primary progressive aphasia. J Addict Dis 35:36-41
Mansoor, Yael; Jastrzab, Laura; Dutt, Shubir et al. (2015) Memory profiles in pathology or biomarker confirmed Alzheimer disease and frontotemporal dementia. Alzheimer Dis Assoc Disord 29:135-40
You, S Christine; Walsh, Christine M; Chiodo, Louis A et al. (2015) Neuropsychiatric Symptoms Predict Functional Status in Alzheimer's Disease. J Alzheimers Dis 48:863-9
Perry, David C; Kramer, Joel H (2015) Reward processing in neurodegenerative disease. Neurocase 21:120-33
Wagshal, Dana; Sankaranarayanan, Sethu; Guss, Valerie et al. (2015) Divergent CSF ? alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 86:244-50
Perry, David C; Sturm, Virginia E; Wood, Kristie A et al. (2015) Divergent processing of monetary and social reward in behavioral variant frontotemporal dementia and Alzheimer disease. Alzheimer Dis Assoc Disord 29:161-4

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