This is a resubmission of a competitive renewal R01 application to continue the research project """"""""Demographic Analysis on Determinants of Healthy Longevity in China"""""""" (PI: Yi Zeng). We are requesting 5-year research support from 7/1/2010 to 6/30/2015, with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral, and genetic factors and their interactions on healthy longevity. More specifically, we plan to achieve our goal through the following research activities. (1) Collect follow-up data on mortality and changes in health status in 2011 and 2014 for those 14,000 interviewees who contributed DNA samples for the first time in 2008. (2) Identify the healthy longevity related genes by genome-wide screening and genotyping with the two-stage study design of population association analysis as well as the convergent statistical analyses. (3) Innovatively apply advanced demographic/statistical methods to analyze the CLHLS multi-wave longitudinal survey data and genotype data produced by this project in an integrated way to estimate the impacts of environmental and genetic risk factors on health and longevity at old ages. In addition to studying the general associations between environmental and genetic factors, we plan to pay particular attention to analyze the effects of environment-gene interactions on healthy longevity. (4) Develop the genotypic and phenotypic database (including health conditions, disability status, behavior, life style, diet, psychological characteristics, survival and death, etc.). We will make this database of the world's largest sample of centenarians, nonagenarians, younger elderly, and middle-aged controls user-friendly and widely available to all interested scholars, while eliminating all information which may be potentially used to identify the individual participants.

Public Health Relevance

This is the resubmission of the competitive renewal R01 application to continue the research project """"""""Demographic Analysis on Determinants of Healthy Longevity in China"""""""" (PI: Yi Zeng), with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral and genetic factors and their interactions on healthy longevity. We emphasize studying factors affecting health at old ages in the context of expanding lifespan, based on well-conducted interdisciplinary research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG023627-08
Application #
8318166
Study Section
Social Sciences and Population Studies Study Section (SSPS)
Program Officer
Patmios, Georgeanne E
Project Start
2004-09-01
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
8
Fiscal Year
2012
Total Cost
$199,719
Indirect Cost
$68,045
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Zeng, Yi; Chen, Huashuai; Ni, Ting et al. (2016) Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages. Rejuvenation Res 19:195-203
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2016) Novel loci and pathways significantly associated with longevity. Sci Rep 6:21243
Gu, Danan; Zhu, Haiyan; Brown, Tyson et al. (2016) Tourism Experiences and Self-Rated Health Among Older Adults in China. J Aging Health 28:675-703
Lv, Y-B; Yin, Z X; Chei, C-L et al. (2016) Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly. J Nutr Health Aging 20:280-7
Zeng, Yi; Chen, Huashuai; Wang, Zhenglian et al. (2015) Implications of changes in households and living arrangements for future home-based care needs and costs for disabled elders in China. J Aging Health 27:519-50
Zeng, Yi; Chen, Huashuai; Ni, Ting et al. (2015) GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. J Gerontol A Biol Sci Med Sci 70:426-33
Zhang, Jiaan; Wu, Liyun (2015) Cigarette smoking and alcohol consumption among Chinese older adults: do living arrangements matter? Int J Environ Res Public Health 12:2411-36
Cheng, Lingguo; Liu, Hong; Zhang, Ye et al. (2015) The impact of health insurance on health outcomes and spending of the elderly: evidence from China's New Cooperative Medical Scheme. Health Econ 24:672-91
Hu, Wen; Lu, Jiehua (2015) Associations of chronic conditions, APOE4 allele, stress factors, and health behaviors with self-rated health. BMC Geriatr 15:137
Feng, Zhixin; Jones, Kelvyn; Wang, Wenfei Winnie (2015) An exploratory discrete-time multilevel analysis of the effect of social support on the survival of elderly people in China. Soc Sci Med 130:181-9

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