This is a resubmission of a competitive renewal R01 application to continue the research project """"""""Demographic Analysis on Determinants of Healthy Longevity in China"""""""" (PI: Yi Zeng). We are requesting 5-year research support from 7/1/2010 to 6/30/2015, with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral, and genetic factors and their interactions on healthy longevity. More specifically, we plan to achieve our goal through the following research activities. (1) Collect follow-up data on mortality and changes in health status in 2011 and 2014 for those 14,000 interviewees who contributed DNA samples for the first time in 2008. (2) Identify the healthy longevity related genes by genome-wide screening and genotyping with the two-stage study design of population association analysis as well as the convergent statistical analyses. (3) Innovatively apply advanced demographic/statistical methods to analyze the CLHLS multi-wave longitudinal survey data and genotype data produced by this project in an integrated way to estimate the impacts of environmental and genetic risk factors on health and longevity at old ages. In addition to studying the general associations between environmental and genetic factors, we plan to pay particular attention to analyze the effects of environment-gene interactions on healthy longevity. (4) Develop the genotypic and phenotypic database (including health conditions, disability status, behavior, life style, diet, psychological characteristics, survival and death, etc.). We will make this database of the world's largest sample of centenarians, nonagenarians, younger elderly, and middle-aged controls user-friendly and widely available to all interested scholars, while eliminating all information which may be potentially used to identify the individual participants.

Public Health Relevance

This is the resubmission of the competitive renewal R01 application to continue the research project Demographic Analysis on Determinants of Healthy Longevity in China (PI: Yi Zeng), with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral and genetic factors and their interactions on healthy longevity. We emphasize studying factors affecting health at old ages in the context of expanding lifespan, based on well-conducted interdisciplinary research. Project Narrative-Public Health Relevance This is the resubmission of the competitive renewal R01 application to continue the research project Demographic Analysis on Determinants of Healthy Longevity in China (PI: Yi Zeng), with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral and genetic factors and their interactions on healthy longevity. We emphasize studying factors affecting health at old ages in the context of expanding lifespan, based on well-conducted interdisciplinary research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG023627-10
Application #
8715660
Study Section
Social Sciences and Population Studies Study Section (SSPS)
Program Officer
Patmios, Georgeanne E
Project Start
2004-09-01
Project End
2015-05-31
Budget Start
2014-06-15
Budget End
2015-05-31
Support Year
10
Fiscal Year
2014
Total Cost
$206,857
Indirect Cost
$70,637
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Gao, Min; Li, Yanyu; Zhang, Shengfa et al. (2017) Does an Empty Nest Affect Elders' Health? Empirical Evidence from China. Int J Environ Res Public Health 14:
Lv, Yue-Bin; Zhu, Peng-Fei; Yin, Zhao-Xue et al. (2017) A U-shaped Association Between Blood Pressure and Cognitive Impairment in Chinese Elderly. J Am Med Dir Assoc 18:193.e7-193.e13
Zeng, Yi; Feng, Qiushi; Hesketh, Therese et al. (2017) Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. Lancet 389:1619-1629
Zeng, Yi; Feng, Qiushi; Gu, Danan et al. (2017) Demographics, phenotypic health characteristics and genetic analysis of centenarians in China. Mech Ageing Dev 165:86-97
Yin, Z; Fei, Z; Qiu, C et al. (2017) Dietary Diversity and Cognitive Function among Elderly People: A Population-Based Study. J Nutr Health Aging 21:1089-1094
Gu, Danan; Zhu, Haiyan; Brown, Tyson et al. (2016) Tourism Experiences and Self-Rated Health Among Older Adults in China. J Aging Health 28:675-703
Lv, Y-B; Yin, Z X; Chei, C-L et al. (2016) Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly. J Nutr Health Aging 20:280-7
Yi, Zeng; George, Linda; Sereny, Melanie et al. (2016) Older parents enjoy better filial piety and care from daughters than sons in China. Am J Med Res (N Y) 3:244-272
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2016) Novel loci and pathways significantly associated with longevity. Sci Rep 6:21243
Zeng, Yi; Chen, Huashuai; Ni, Ting et al. (2016) Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages. Rejuvenation Res 19:195-203

Showing the most recent 10 out of 60 publications