This study is related to the interest area outlined in PA-18-591, specifically, the expansion of projects to include work related to Alzheimer?s Disease and Related Dementias (ADRD). There is increasing evidence that Alzheimer?s disease and related dementias have their origins much earlier in the life course than when symptoms occur. An individual?s occupation and work life are often their longest and most frequent social exposures; risk factors that occur or cumulate during working years represent an important area of focus in understanding potential dementia prevention or intervention. Still, data limitations have rendered study difficult.
The aim of this project is to use the rich administrative data available from the Alcoa cohort to examine occupational and individual risk factors and working conditions during midlife on the risk of Alzheimer?s disease and dementia in later-life. Specifically, we will explore four risk factors that occur and/or cumulate during working years: the role of depression and depressive symptoms; hearing impairment; chronic sleep deprivation, as measured by long working hours; and cumulative exposure to particulate matter. The detailed and longitudinal nature of these data?often spanning over a decade of a workers? tenure?represent a significant contribution to the efforts to understand the role of occupational risk factors to ADRD. This research will shed light on potentially modifiable risk factors of ADRD that occur in midlife and as a part of one?s occupational context. Given the importance of work and working conditions in shaping health, understanding the contribution of such factors offers new opportunities for prevention and intervention of ADRD.
The Alcoa research infrastructure?linking quantitative exposure measures to myriad hazards of active workers whose behavior, social environment and health status from pre-employment through retirement to death are fully observed?has recently acquired a sizeable data linkage that now makes it possible to identify Alzheimer?s disease and dementia in previously-employed workers. This project examines a number of occupational risk factors associated with ADRD risk using longitudinally rich data. We expect that this project will elucidate the relationship between work in mid-life and later-life ADRD risk.
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| Pensa, Mellisa A; Galusha, Deron H; Cantley, Linda F (2018) Patterns of Opioid Prescribing and Predictors of Chronic Opioid Use in an Industrial Cohort, 2003 to 2013. J Occup Environ Med 60:457-461 |
| Altassan, Khaled Abdulrahman; Sakr, Carine J; Galusha, Deron et al. (2018) Risk of Injury by Unionization: Survival Analysis of a Large Industrial Cohort. J Occup Environ Med 60:827-831 |
| Liu, Sa; Noth, Elizabeth; Eisen, Ellen et al. (2018) Respirator use and its impact on particulate matter exposure in aluminum manufacturing facilities. Scand J Work Environ Health 44:547-554 |
| Eisenberg, Michael L; Galusha, Deron; Kennedy, William A et al. (2018) The Relationship between Neonatal Circumcision, Urinary Tract Infection, and Health. World J Mens Health 36:176-182 |
| Sayler, Stephanie K; Rabinowitz, Peter M; Galusha, Deron et al. (2018) Hearing Protector Attenuation and Noise Exposure Among Metal Manufacturing Workers. Ear Hear : |
| Izano, Monika A; Brown, Daniel M; Neophytou, Andreas M et al. (2018) Contrasting Causal Effects of Workplace Interventions. Epidemiology 29:542-546 |
| Sayler, Stephanie K; Rabinowitz, Peter M; Cantley, Linda F et al. (2018) Costs and effectiveness of hearing conservation programs at 14 US metal manufacturing facilities. Int J Audiol 57:S3-S11 |
| Tessier-Sherman, Baylah; Galusha, Deron; Cantley, Linda F et al. (2017) Occupational noise exposure and risk of hypertension in an industrial workforce. Am J Ind Med 60:1031-1038 |
| Domingue, Benjamin W; Belsky, Daniel W; Harrati, Amal et al. (2017) Mortality selection in a genetic sample and implications for association studies. Int J Epidemiol 46:1285-1294 |
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