The capacity to comprehend language lies at the core of a person's ability to gain information from the environment, perform everyday tasks, and maintain normal social relations. The critical role of the left hemisphere (LH) in supporting these processes has served as a paradigmatic example of neural specialization for higher cognitive functions. However, it is increasingly apparent that the right hemisphere (RH) also makes important, distinctive contributions to language comprehension.
The aim of the proposed research is to delineate how processing resources distributed across the 2 cerebral hemispheres come together in real time to mediate language and how these processes and their underlying mechanisms change over the course of normal aging, with the long-term goal of elucidating factors that can protect against or compensate for age-, trauma-, or disease-related reductions in language capabilities. The proposal puts forward and tests a theoretical framework, based on recent neuropsychological, behavioral, and event-related brain potential (ERP) studies of language asymmetry, which asserts that LH and RH language comprehension differ because comprehension is cognitively and neurally integrated with language production only in the LH. 17 proposed experiments, which use visual half-field presentation techniques to preferentially stimulate 1 hemisphere and measure ERPs in order to examine asymmetries with temporal and functional specificity, test the hypotheses that (1) topdown connections have a greater impact on LH language comprehension, with concomitant implications for when and how difference information types are brought to bear and for the nature and timecourse of processing difficulties that may be encountered, (2) RH processing lead to more veridical representations of verbal stimuli, which can aid explicit and implicit retention over long time intervals and protect against certain types of memory errors, and (3) older adults show reduced functional hemispheric specialization, with attendant changes in both language comprehension and verbal memory. These experiments lay the foundation for an understanding of the computational and neurobiological roots of the complex and critical cognitive skill that is language.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG026308-03
Application #
7255413
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Wagster, Molly V
Project Start
2005-07-15
Project End
2010-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
3
Fiscal Year
2007
Total Cost
$250,863
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Payne, Brennan R; Federmeier, Kara D (2018) Contextual constraints on lexico-semantic processing in aging: Evidence from single-word event-related brain potentials. Brain Res 1687:117-128
Rommers, Joost; Federmeier, Kara D (2018) Predictability's aftermath: Downstream consequences of word predictability as revealed by repetition effects. Cortex 101:16-30
Payne, Brennan R; Federmeier, Kara D (2017) Event-related brain potentials reveal age-related changes in parafoveal-foveal integration during sentence processing. Neuropsychologia 106:358-370
Payne, Brennan R; Federmeier, Kara D (2017) Pace Yourself: Intraindividual Variability in Context Use Revealed by Self-paced Event-related Brain Potentials. J Cogn Neurosci 29:837-854
Rommers, Joost; Dickson, Danielle S; Norton, James J S et al. (2017) Alpha and theta band dynamics related to sentential constraint and word expectancy. Lang Cogn Neurosci 32:576-589
Lucas, Heather D; Hubbard, Ryan J; Federmeier, Kara D (2017) Flexible conceptual combination: Electrophysiological correlates and consequences for associative memory. Psychophysiology 54:833-847
Stites, Mallory C; Payne, Brennan R; Federmeier, Kara D (2017) Getting ahead of yourself: Parafoveal word expectancy modulates the N400 during sentence reading. Cogn Affect Behav Neurosci 17:475-490
Leckey, Michelle; Federmeier, Kara D (2017) Age-related shifts in hemispheric dominance for syntactic processing. Psychophysiology 54:1929-1939
Dickson, Danielle S; Federmeier, Kara D (2017) The language of arithmetic across the hemispheres: An event-related potential investigation. Brain Res 1662:46-56
Stites, Mallory C; Federmeier, Kara D; Christianson, Kiel (2016) Do Morphemes Matter when Reading Compound Words with Transposed Letters? Evidence from Eye-Tracking and Event-Related Potentials. Lang Cogn Neurosci 31:1299-1319

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