Puerto Rican older adults living in the U.S. mainland have been identified as a group highly at-risk of excess chronic conditions. While it is clear that Puerto Ricans suffer from several chronic health conditions, much less is known about how osteoporosis, a major public health threat in the U.S., affects this population. We propose to extend our work in the currently ongoing cohort of 1,200 Puerto Rican adults, aged 50-75 y at baseline, who are participating in the Boston Puerto Rican Center on Population Health and Health Disparities [NIA Grant No. 5P01AG023394-02]. Because considerable amounts of data are already being collected with this cohort, the addition of bone related measurements to this study will provide a highly efficient way to examine additional hypotheses on nutrition and bone mineral density.
We aim to 1) assess the status of bone mineral density in a group of Boston Puerto Rican adults, aged 52-77 y; 2) examine associations between dietary factors and BMD of the hip, spine, and total body and markers of bone turnover; 3) examine associations between stress and inflammation and BMD of the hip, spine, heel, and total body and markers of bone turnover; and 4)examine how dietary factors modulate the association between candidate genes and measures of bone health including BMD of the hip, spine, and total body and markers of bone turnover. This proposed project addresses the mission defined in the new NIH roadmap, to improve the nation's health by uncovering new knowledge in the prevention, detection, diagnosis, and treatment of disease and disability, with the ultimate goal of reducing and eliminating health disparities among racial and ethnic minorities. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG027087-01A2
Application #
7209940
Study Section
Kidney, Nutrition, Obesity and Diabetes (KNOD)
Program Officer
Nayfield, Susan G
Project Start
2007-04-01
Project End
2010-02-28
Budget Start
2007-04-01
Budget End
2008-02-29
Support Year
1
Fiscal Year
2007
Total Cost
$634,800
Indirect Cost
Name
Tufts University
Department
Type
Organized Research Units
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
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Noel, Sabrina E; Arevalo, Sandra; Smith, Caren E et al. (2017) Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study. J Bone Miner Metab 35:448-455
Sotos-Prieto, M; Bhupathiraju, S N; Falcon, L M et al. (2016) Association between a Healthy Lifestyle Score and inflammatory markers among Puerto Rican adults. Nutr Metab Cardiovasc Dis 26:178-84
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Bigornia, Sherman J; Lichtenstein, Alice H; Harris, William S et al. (2016) Associations of erythrocyte fatty acid patterns with insulin resistance. Am J Clin Nutr 103:902-9
Niu, Jinya; Sahni, Shivani; Liao, Susu et al. (2015) Association between Sleep Duration, Insomnia Symptoms and Bone Mineral Density in Older Boston Puerto Rican Adults. PLoS One 10:e0132342
Sotos-Prieto, Mercedes; Bhupathiraju, Shilpa N; Falcón, Luis M et al. (2015) A Healthy Lifestyle Score Is Associated with Cardiometabolic and Neuroendocrine Risk Factors among Puerto Rican Adults. J Nutr 145:1531-40
Bhupathiraju, Shilpa N; Lichtenstein, Alice H; Dawson-Hughes, Bess et al. (2013) Adherence to the 2006 American Heart Association Diet and Lifestyle Recommendations for cardiovascular disease risk reduction is associated with bone health in older Puerto Ricans. Am J Clin Nutr 98:1309-16
Ye, Xingwang; Gao, Xiang; Scott, Tammy et al. (2011) Habitual sugar intake and cognitive function among middle-aged and older Puerto Ricans without diabetes. Br J Nutr 106:1423-32
Bhupathiraju, Shilpa N; Dawson-Hughes, Bess; Hannan, Marian T et al. (2011) Centrally located body fat is associated with lower bone mineral density in older Puerto Rican adults. Am J Clin Nutr 94:1063-70

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