This proposal requests support for the investigators in the Clinical Centers in the Study of Osteoporotic Fractures (SOF) to analyze data, publish results, and continue scientific participation in SOF during the 4th and 5th years of our competitively renewed and (partially) funded 5 year study. We are NOT requesting support for collecting data or assaying samples and we have NOT changed any aspect of the funded 5 year study. SOF was renewed in August 2006 to study why some women achieve excellent lower extremity and cognitive function in the 9th and 10th decades of life and why some women have maintained healthy trajectories of lower extremity and cognitive function over 10 years of follow-up. We are specifically testing whether renal function, inflammation, and vitamin D are important to maintaining and achieving high levels of function and lower risks of falls, and hip fractures. Each SOF Clinical Center PI took the lead in developing one of the SOF Aims. NIH funded our Year 20 Exam in which we are measuring cognitive and lower extremity function. We are on target to complete the visits by the end of September, 2008 so that we can begin to select and pull samples and start biomarker assays later in that 3rd year. The bulk of the data will be analyzed and papers produced in the 4th and 5th years of the renewal. Investigators at the Clinical Centers - including young investigators - would do most of that work. The Coordinating Center was funded for 5 years. However, Clinical Centers were funded for only 3 years (8/1/06-7/31/09) just to complete the Exam. The 3 year limit on Clinical Center funding would - inadvertently - prevent the Clinical Center investigators from analyzing and publishing results from the aims they developed. Therefore, we request support for the SOF Clinical Center investigators to analyze and publish results from this funded competitive renewal during the 4th and 5th years of our renewal and continue their essential participation in the scientific activities of SOF. In addition, NIA requested that we include a plan for public data sharing for SOF in this proposal. Our plan builds on our successful public access web portal, SOF Online, and proposes to add downloadable and documented public release data sets to the website to allow external investigators direct access to identified SOF data.

Public Health Relevance

The Study of Osteoporotic Fractures (SOF) was competitively renewed to study why some women achieve and maintain high cognitive and physical function, and low risk of falls and fractures in the 9th and 10th decade of life. The SOF Coordinating Center was funded for 5 years;SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG027574-25
Application #
7584265
Study Section
Special Emphasis Panel (ZRG1-HOP-W (60))
Program Officer
Sherman, Sherry
Project Start
2009-09-15
Project End
2011-08-31
Budget Start
2009-09-15
Budget End
2010-08-31
Support Year
25
Fiscal Year
2009
Total Cost
$158,000
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
Diem, Susan J; Vo, Tien N; Langsetmo, Lisa et al. (2018) Impact of Competing Risk of Mortality on Association of Cognitive Impairment With Risk of Hip Fracture in Older Women. J Bone Miner Res 33:1595-1602
Ensrud, Kristine E; Kats, Allyson M; Schousboe, John T et al. (2018) Frailty Phenotype and Healthcare Costs and Utilization in Older Women. J Am Geriatr Soc 66:1276-1283
Black, Dennis M; Cauley, Jane A; Wagman, Rachel et al. (2018) The Ability of a Single BMD and Fracture History Assessment to Predict Fracture Over 25 Years in Postmenopausal Women: The Study of Osteoporotic Fractures. J Bone Miner Res 33:389-395
Mariani, Sara; Tarokh, Leila; Djonlagic, Ina et al. (2018) Evaluation of an automated pipeline for large-scale EEG spectral analysis: the National Sleep Research Resource. Sleep Med 47:126-136
LeBlanc, Erin S; Rizzo, Joanne H; Pedula, Kathryn L et al. (2018) Long-Term Weight Trajectory and Risk of Hip Fracture, Falls, Impaired Physical Function, and Death. J Am Geriatr Soc 66:1972-1979
Byers, Amy L; Lui, Li-Yung; Vittinghoff, Eric et al. (2018) Burden of Depressive Symptoms Over 2 Decades and Risk of Nursing Home Placement in Older Women. J Am Geriatr Soc 66:1895-1901
Sun, Jianping; Oualkacha, Karim; Forgetta, Vincenzo et al. (2018) Exome-wide rare variant analyses of two bone mineral density phenotypes: the challenges of analyzing rare genetic variation. Sci Rep 8:220
Ward, Michael E; Gelfand, Jeffrey M; Lui, Li-Yung et al. (2018) Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment. Ann Neurol 83:730-738
Schousboe, John T; Kats, Allyson M; Langsetmo, Lisa et al. (2018) Associations of recent weight loss with health care costs and utilization among older women. PLoS One 13:e0191642
Diem, Susan J; Lui, Li-Yung; Langsetmo, Lisa et al. (2018) Effects of Mobility and Cognition on Maintenance of Independence and Survival Among Women in Late Life. J Gerontol A Biol Sci Med Sci 73:1251-1257

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