7. ABSTRACT We have discovered a series of chemical compounds that delay the onset of age-related pathology and extend lifespan. These compounds were identified in focused chemical screens and high throughput screens of both synthetic compounds and natural products. Here we propose to identify the mechanism of lifespan extension with a focus on vitamin D which we have shown maintains protein homeostasis and extends lifespan in C. elegans. This will uncover novel mechanisms for interventions in aging and age-related disease.

Public Health Relevance

The development of preventative therapies aimed at reducing or delaying age-related disease must be a priority for the biomedical community. We and others have proposed that targeting aging mechanisms contribute to a number of age-related diseases. We have identified molecules, including vitamin D in the nematode C. elegans that slow aging. We propose to elucidate the mechanisms at play.

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National Institute on Aging (NIA)
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Cellular Mechanisms in Aging and Development Study Section (CMAD)
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Guo, Max
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Buck Institute for Age Research
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Lucanic, Mark; Plummer, W Todd; Chen, Esteban et al. (2017) Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects. Nat Commun 8:14256
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