Our overarching aim, consistent with a life span perspective, is enhancing understanding of how childhood and adult adversities and relationships, contribute to early midlife adult physical health outcomes. A second central aim is examining how individuals'salient demographic characteristics-ethnicity/race and socioeconomic position-influence specific health outcomes (metabolic syndrome, cardiovascular disease, diabetes mellitus) and their predictors (e.g., specific adversities, health risk behaviors, individual, and relationship dimensions). This multi-method (psychosocial, sociological, and metabolic approaches) project will examine links from early and ongoing adversities to early signs of physical illness, not yet expressed as impairing symptoms. Collaborators include developmental psychologists, internal medicine/metabolism expert, psychiatrists, and a multivariate longitudinal statistician. Much evidence points to childhood adversity and/or sustained relationship stress rendering individuals vulnerable to developing physical health problems, especially cardiovascular disease (CVD), at a relatively young age. This """"""""accelerated aging"""""""" is likely associated with specific health risk behaviors. We specifically focus on hypothesized influences of 1) salient adverse experiences and individual characteristics, associated with economic hardship, racism, and exposure to violence, 2) perturbations of relationships in families-marriage and romantic relationships--as they influence midlife health outcomes, and 3) how variations in midlife adults'midlife physical health are influenced by their current mental health, and close social relationships (peer and family). These individual and relationship dimensions represent both protective and vulnerability factors linking early experience and midlife physical illness. At a next level we address contributions of larger contexts (beyond family) through including two deliberately different samples: from our ongoing midlife longitudinal project;and a second, community sample of Black adults, same age and socioeconomic range as our current high and low risk White sample. This new sample (n = 250), recruited through a community quota sampling design, will lead to refining planned analyses considering psychosocial (relationship and individual) predictions of health related outcomes across contrasting ethnic/racial groups and economic strata.
Four specific aims convey our new directions: 1) Assessment of Theoretically and Clinically Significant Physical Health Outcomes, 2) Adversity and Relationship Predictors of Midlife Physical Health Status, 3) Individual Predictors of Midlife Physical Health Status, and 4) The unfolding of relationship adversities, individual characteristics and physical health changes within midlife. We will examine the fourth aim through a longitudinal approach, following participants every 6 months (over 2.5 years) on acute and chronic stressors, social supports, competences, changing health status, and health risk behaviors between baseline and later physiological health risk assessments.
Relevance Our proposed study focuses on metabolic syndrome and diabetes, precursors to cardiac health problems, which are prevalent in middle age. It is important to study psychological symptoms, along with physical symptoms, because often the physical symptoms of cardiovascular health problems are unnoticeable until the patient's health is severely endangered. With the ability to alert patients of their risk of developing cardiovascular disease, patients can take an active preventive measure to protect themselves against potential future health problems.
|Ko, Byung-Joon; Park, Kyung Hee; Shin, Sangah et al. (2016) Diet quality and diet patterns in relation to circulating cardiometabolic biomarkers. Clin Nutr 35:484-90|
|Gavrieli, Anna; Farr, Olivia M; Davis, Cynthia R et al. (2015) Early life adversity and/or posttraumatic stress disorder severity are associated with poor diet quality, including consumption of trans fatty acids, and fewer hours of resting or sleeping in a US middle-aged population: A cross-sectional and prospective Metabolism 64:1597-610|
|Farr, O M; Ko, B-J; Joung, K E et al. (2015) Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk. Nutr Metab Cardiovasc Dis 25:479-88|
|Davis, Cynthia R; Dearing, Eric; Usher, Nicole et al. (2014) Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors. Metabolism 63:199-206|
|Davis, Cynthia R; Usher, Nicole; Dearing, Eric et al. (2014) Attachment and the metabolic syndrome in midlife: the role of interview-based discourse patterns. Psychosom Med 76:611-21|
|Joung, Kyoung Eun; Park, Kyung-Hee; Zaichenko, Lesya et al. (2014) Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults. J Clin Endocrinol Metab 99:E1055-60|
|Liu, Xiaowen; Hamnvik, Ole-Petter R; Chamberland, John P et al. (2014) Circulating alanine transaminase (ALT) and Î³-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: the prospective Cyprus Metabolism Study. Metabolism 63:773-82|
|Park, Kyung Hee; Zaichenko, Lesya; Peter, Patricia et al. (2014) Diet quality is associated with circulating C-reactive protein but not irisin levels in humans. Metabolism 63:233-41|
|Matarese, Giuseppe; La Rocca, Claudia; Moon, Hyun-Seuk et al. (2013) Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia. Proc Natl Acad Sci U S A 110:E818-27|
|Moon, Hyun-Seuk; Dalamaga, Maria; Kim, Sang-Yong et al. (2013) Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals. Endocr Rev 34:377-412|
Showing the most recent 10 out of 40 publications