We propose to test the novel hypothesis that a persistent history of psychiatric disorder might accelerate individuals'risk of progression toward age-related disease. Specifically, the hypothesis is that people who suffer chronic or recurrent psychiatric disorders during early adulthood will, already by age 38, show cognitive decline and abnormal status on sub-clinical biomarkers that are known to be prognostic early warning signs for late-life diseases, frailty and disability. Rather than focus on psychiatric disorders as an outcome, we study psychiatric disorders as a potentially preventable `exposure'that may accelerate aging. METHOD: We will test this hypothesis in the context of the Dunedin Study, a longitudinal study from birth to age 38 of a representative birth cohort of men and women (N=1037). A unique design feature is that baseline physical health and baseline neuropsychological assessments were carried out from birth to age 13, prior to the onset of most psychiatric disorders. To our knowledge, no other study of the health consequences of psychiatric disorder has these prospective baseline data, which are essential to test whether health and neuropsychological functions have deteriorated in individuals with persistent psychiatric disorder. Cohort members'psychiatric histories of recurrent Depression, recurrent Anxiety, chronic Schizophrenia-syndrome, persistent Alcohol Dependence, and persistent Cannabis Dependence will be defined using data from repeated assessments across 20 intervening years in this longitudinal study. Here we propose to assess the cohort again at age 38, for new data collection. We will assess sensitive outcome measures of sub-clinical health status that are known predictors of age-related diseases in later life: neuropsychological tests of memory and executive functions, the metabolic syndrome, immunological biomarkers, and shortened telomere length. These markers were chosen because they show meaningful variation among people in their late 30's and are known early warning signs for dementia, cardiovascular disease and diabetes. INNOVATION AND SIGNIFICANCE: Life expectancy is growing longer and longer. Policy makers and citizens are concerned that our extra years of life should be healthy, productive, and enjoyable, not extra years of disease and disability. The hope of preventing age-related diseases and of increasing health expectancy requires research to identify candidate risk targets that can be treated successfully, in early- to-middle adulthood. If the hypothesis that psychiatric disorder accelerates the sub-clinical progression toward age-related disease were shown to be true by our proposed research, this would imply that age- related disease could be reduced by successfully treating psychiatric disorders early in life.

Public Health Relevance

As life expectancy grows longer and longer, policy makers and citizens are concerned that our extra years should be healthy, productive, and enjoyable, not extra years of disease and disability. The hope of preventing age-related diseases requires research to identify candidate risk targets that can be treated successfully, in early-to-middle adulthood, before the onset of age-related disease. If the hypothesis that psychiatric disorder accelerates the sub-clinical progression toward age-related disease were shown to be true by our proposed research, this would imply that age-related diseases could be reduced by successfully treating psychiatric disorders early in life.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG032282-02
Application #
7774364
Study Section
Special Emphasis Panel (ZRG1-HOP-D (02))
Program Officer
Spotts, Erica L
Project Start
2009-03-01
Project End
2014-02-28
Budget Start
2010-03-15
Budget End
2011-02-28
Support Year
2
Fiscal Year
2010
Total Cost
$500,898
Indirect Cost
Name
Duke University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Beckley, Amber L; Caspi, Avshalom; Broadbent, Jonathan et al. (2017) Association of Childhood Blood Lead Levels With Criminal Offending. JAMA Pediatr :
Rivenbark, Joshua G; Odgers, Candice L; Caspi, Avshalom et al. (2017) The high societal costs of childhood conduct problems: evidence from administrative records up to age 38 in a longitudinal birth cohort. J Child Psychol Psychiatry :
Domingue, Benjamin W; Belsky, Daniel W (2017) The social genome: Current findings and implications for the study of human genetics. PLoS Genet 13:e1006615
Schaefer, Jonathan D; Scult, Matthew A; Caspi, Avshalom et al. (2017) Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts. Dev Psychopathol :1-15
Belsky, Daniel W; Caspi, Avshalom; Cohen, Harvey J et al. (2017) Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan. Aging Cell 16:644-651
Schaefer, Jonathan D; Caspi, Avshalom; Belsky, Daniel W et al. (2017) Enduring mental health: Prevalence and prediction. J Abnorm Psychol 126:212-224
Danese, Andrea; Moffitt, Terrie E; Arseneault, Louise et al. (2017) The Origins of Cognitive Deficits in Victimized Children: Implications for Neuroscientists and Clinicians. Am J Psychiatry 174:349-361
van Roode, Thea; Sharples, Katrina; Dickson, Nigel et al. (2017) Life-Course Relationship between Socioeconomic Circumstances and Timing of First Birth in a Birth Cohort. PLoS One 12:e0170170
Domingue, Benjamin W; Liu, Hexuan; Okbay, Aysu et al. (2017) Genetic Heterogeneity in Depressive Symptoms Following the Death of a Spouse: Polygenic Score Analysis of the U.S. Health and Retirement Study. Am J Psychiatry 174:963-970
Williams, M J A; Milne, B J; Ambler, A et al. (2017) Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. Int J Obes (Lond) 41:1355-1360

Showing the most recent 10 out of 90 publications