Ethnic differences in clinical pain have been observed across numerous acute and chronic conditions, with African Americans often reporting higher levels of pain and disability. While multiple factors inevitably determine these ethnic differences, we have proposed that ethnic differences in endogenous pain modulation may represent an important contributor. During the previous funding cycle, we have gathered substantial evidence documenting differences in experimental pain sensitivity and endogenous pain modulation in a population of healthy African Americans, Hispanic Americans, and non-Hispanic whites. Relative to non- Hispanic whites, both minority groups evinced significantly greater sensitivity to suprathreshold heat, cold, and ischemic stimuli. Moreover, compared to non-Hispanic whites, African Americans showed reduced diffuse noxious inhibitory controls (DNIC), suggesting diminished pain inhibitory capacity. In this competing renewal application, we propose to translate our findings to a clinical population by addressing the following specific aims: 1) to characterize ethnic differences in experimental pain sensitivity, endogenous pain inhibition, clinical pain and pain-related disability among older African Americans and non-Hispanic whites with knee osteoarthritis (OA). In order to accomplish this aim, we will obtain psychophysical measures of pain perception and pain inhibition (i.e. diffuse noxious inhibitory controls, DNIC) as well as measures of clinical pain and disability;2) to determine ethnic group differences in biological, psychological, and sociocultural factors and their contribution to pain sensitivity, pain inhibition, and clinical pain and disability among older African Americans and non-Hispanic whites with knee OA;and 3) to determine whether the combination of laboratory measures of pain sensitivity and pain inhibition along with biological, psychological and sociocultural factors mediate ethnic group differences in clinical pain and pain-related disability among older African Americans and non-Hispanic whites with knee OA. We anticipate that, relative to non-Hispanic whites, African Americans will report higher levels of OA-related pain and disability, and these differences in clinical pain and disability will be mediated by ethnic group differences in laboratory measures of pain sensitivity and pain inhibition, in combination with biological and psychosocial variables. Support for our hypotheses will provide novel information regarding the clinical utility of laboratory measures of endogenous pain modulation for explaining ethnic group differences in OA-related pain and disability.
Ethnic differences in clinical pain and pain-related disability have been well documented, and ethnic differences in experimental pain sensitivity have been reported among healthy adults. The goal of this project is to determine whether ethnic differences in laboratory measures of pain sensitivity and pain inhibition, in combination with biological and psychosocial variables, mediate ethnic group differences in clinical pain and disability among African Americans and non-Hispanic whites with knee osteoarthritis.
|Herbert, Matthew S; Goodin, Burel R; Bulls, Hailey W et al. (2016) Ethnicity, Cortisol, and Experimental Pain Responses among Persons with Symptomatic Knee Osteoarthritis. Clin J Pain :|
|Cardoso, Josue S; Riley 3rd, Joseph L; Glover, Toni et al. (2016) Experimental pain phenotyping in community-dwelling individuals with knee osteoarthritis. Pain 157:2104-14|
|Bartley, Emily J; King, Christopher D; Sibille, Kimberly T et al. (2016) Enhanced Pain Sensitivity Among Individuals With Symptomatic Knee Osteoarthritis: Potential Sex Differences in Central Sensitization. Arthritis Care Res (Hoboken) 68:472-80|
|Bulls, Hailey W; Goodin, Burel R; McNew, Myriah et al. (2016) Minority Aging and Endogenous Pain Facilitatory Processes. Pain Med 17:1037-48|
|Glover, Toni L; Goodin, Burel R; King, Christopher D et al. (2015) A Cross-sectional Examination of Vitamin D, Obesity, and Measures of Pain and Function in Middle-aged and Older Adults With Knee Osteoarthritis. Clin J Pain 31:1060-7|
|Petrov, Megan E; Goodin, Burel R; Cruz-Almeida, Yenisel et al. (2015) Disrupted sleep is associated with altered pain processing by sex and ethnicity in knee osteoarthritis. J Pain 16:478-90|
|Cruz-Almeida, Yenisel; Sibille, Kimberly T; Goodin, Burel R et al. (2014) Racial and ethnic differences in older adults with knee osteoarthritis. Arthritis Rheumatol 66:1800-10|
|Petrov, Megan E; Sawyer, Patricia; Kennedy, Richard et al. (2014) Benzodiazepine (BZD) use in community-dwelling older adults: Longitudinal associations with mobility, functioning, and pain. Arch Gerontol Geriatr 59:331-7|
|Goodin, Burel R; Bulls, Hailey W; Herbert, Matthew S et al. (2014) Temporal summation of pain as a prospective predictor of clinical pain severity in adults aged 45 years and older with knee osteoarthritis: ethnic differences. Psychosom Med 76:302-10|
|Riley 3rd, Joseph L; Cruz-Almeida, Yenisel; Glover, Toni L et al. (2014) Age and race effects on pain sensitivity and modulation among middle-aged and older adults. J Pain 15:272-82|
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