Studies of aging in wild animal populations, especially in our primate relatives, offer a unique set of potential benefits for understanding the processes and patterns governing human aging. The comparative perspective that animal models provide can both bring to light general principles and mechanisms that govern the aging process across species, and can highlight human-specific characteristics of aging. Additionally, in some cases datasets that are extremely difficult to gather in humans (such as fine-scaled behavioral data in natural social settings) are more readily obtainable in wild primate populations. However, despite keen interest in aging as a human health concern and the enormous progress in this area in recent decades, patterns of aging in wild animals - age-related changes not just in survival, but also in social behavior, hormone profiles, and other aspects of health and functioning - remain almost entirely undescribed. Our detailed, longitudinal data from a population of wild baboons in southern Kenya provides clear evidence both that senescence occurs, and that considerable variance among individuals is seen both in lifespan and in functional declines with age. Baboons live in stable social groups, and individuals within groups share common environments, so physical and demographic differences alone cannot account for the observed variance in the aging process and in lifespan. However, the quality and robustness of individual social relationships do vary among individuals, both within and between social groups, and this variation has both physiological and functional consequences for baboons. These results have brought social connectedness to the foreground in our ongoing, integrative analysis of variance in lifetime outcomes in this population, and have set the stage for a detailed investigation of the dynamics of social connectedness and its relationship to aging. The goals of the proposed work are to identify the components, physiological correlates, and consequences of social connectedness in the context of aging, and to identify genetic and environmental sources of variance in social connectedness. We will test the hypotheses that, in wild nonhuman primates as in humans, social connectedness is a predictor of health and well being throughout the life course;that this effect is independent of density;and that social connectedness declines with age. We will then investigate the relationship between genetic variation in a set of known biological pathways and social connectedness phenotypes. Finally, we will integrate the effects of genetic variation and environmental variation into a life span approach, using a time-series model. We will ask whether the effects that occur in earlier stages of life propagate into late life, or if social connectedness in late life is a relatively independent phenomenon. This analysis will aid in identifying stages during the life course in which prediction of and/or intervention in aging- related outcomes may be most fruitful.

Public Health Relevance

Mechanisms and Consequences of Social Connectedness in a Wild Primate Population: The proposed research will investigate health and well being during aging in a natural population of wild primates, which are closely related to humans and share key similarities, but also important differences. The research will specifically examine the contribution of social connectedness to aging-related outcomes in a natural setting, as well as the genetic and environmental contributors to social connectedness itself. This will offer potential benefits for human health by illuminating important opportunities for, and constraints on, alleviating age- related declines in human health and survival.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG034513-05
Application #
8531109
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1 (M1))
Program Officer
Gerald, Melissa S
Project Start
2009-09-15
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$323,125
Indirect Cost
$66,452
Name
Duke University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Gesquiere, Laurence R; Ziegler, Toni E; Chen, Patricia A et al. (2014) Measuring fecal testosterone in females and fecal estrogens in males: comparison of RIA and LC/MS/MS methods for wild baboons (Papio cynocephalus). Gen Comp Endocrinol 204:141-9
Archie, Elizabeth A; Altmann, Jeanne; Alberts, Susan C (2014) Costs of reproduction in a long-lived female primate: injury risk and wound healing. Behav Ecol Sociobiol 68:1183-1193
Archie, Elizabeth A; Tung, Jenny; Clark, Michael et al. (2014) Social affiliation matters: both same-sex and opposite-sex relationships predict survival in wild female baboons. Proc Biol Sci 281:
Fitzpatrick, Courtney L; Altmann, Jeanne; Alberts, Susan C (2014) Sources of variance in a female fertility signal: exaggerated estrous swellings in a natural population of baboons. Behav Ecol Sociobiol 68:1109-1122
Markham, A Catherine; Guttal, Vishwesha; Alberts, Susan C et al. (2013) When good neighbors don't need fences: Temporal landscape partitioning among baboon social groups. Behav Ecol Sociobiol 67:875-884
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Onyango, Patrick Ogola; Gesquiere, Laurence R; Altmann, Jeanne et al. (2013) Testosterone positively associated with both male mating effort and paternal behavior in Savanna baboons (Papio cynocephalus). Horm Behav 63:430-6
Alberts, Susan C; Altmann, Jeanne; Brockman, Diane K et al. (2013) Reproductive aging patterns in primates reveal that humans are distinct. Proc Natl Acad Sci U S A 110:13440-5
Runcie, Daniel E; Wiedmann, Ralph T; Archie, Elizabeth A et al. (2013) Social environment influences the relationship between genotype and gene expression in wild baboons. Philos Trans R Soc Lond B Biol Sci 368:20120345
Babbitt, Courtney C; Tung, Jenny; Wray, Gregory A et al. (2012) Changes in gene expression associated with reproductive maturation in wild female baboons. Genome Biol Evol 4:102-9

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