Abstract

This application requests support for the assay of venous blood biomarker samples now collected in the fall of 2011 in the China Health and Retirement Longitudinal Study (CHARLS). This is a competing revision to an existing R01 grant that will support the collection of the first two national waves of the CHARLS panel, the first was fielded in 2011 and the second in 2013. The China Health and Retirement Longitudinal Study (CHARLS) is a survey of the elderly in China, run by the National School for Development (China Center for Economic Research) at Peking University, together with the Chinese Center for Disease Control and Prevention (CDC) in the Ministry of Health. It is based on a sample of households with members aged 45 years and older... It is designed to produce a high quality public micro-database, which can provide a wide range of information from socio-economic status to health conditions, to serve the needs of scientific research on the elderly in China. CHARLS is also designed to allow comparisons with other studies in the Health and Retirement Study (HRS) family of studies. With the support requested in this application we will assay venous blood collected in wave 1 of the national study from approximately 17,600 people for indicators of the level of inflammation, glycosylated hemoglobin, plasma glucose, lipids, and kidney functioning This will allow the comparison of levels of these biomarkers with socioeconomic, behavioral and contextual variables within China, with the comparison of levels and links with other variables other international surveys.

Public Health Relevance

The China Health and Retirement Longitudinal Study (CHARLS) will enrich the international landscape of aging studies. CHARLS follows closely the format and content of existing Health and Retirement Studies around the world in order to provide the capability for scholars to engage in comparative studies as well as studies of the special conditions in China. The first two national waves of CHARLS are scheduled for 2011 and 2013. This competitive revision will enable CHARLS to add results on important biomarkers from venous blood samples collected during the first wave of data collection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG037031-03S1
Application #
8369327
Study Section
Special Emphasis Panel (ZRG1-SSPS-H (09))
Program Officer
Phillips, John
Project Start
2010-05-15
Project End
2013-04-30
Budget Start
2012-09-01
Budget End
2013-04-30
Support Year
3
Fiscal Year
2012
Total Cost
$423,265
Indirect Cost
$2,372

  Institution

Name
Peking University
Department
Type
DUNS #
653934935
City
Beijing
State
Country
China
Zip Code
10087-1

  Publications

Sha, Tingting; Cheng, Wenwei; Yan, Yan (2018) Prospective associations between pulse pressure and cognitive performance in Chinese middle-aged and older population across a 5-year study period. Alzheimers Res Ther 10:29
Qin, Tingting; Liu, Wenhua; Yin, Minghui et al. (2017) Body mass index moderates the relationship between C-reactive protein and depressive symptoms: evidence from the China Health and Retirement Longitudinal Study. Sci Rep 7:39940
Zhang, Chuanchuan; Lei, Xiaoyan; Strauss, John et al. (2017) Health Insurance and Health Care among the Mid-Aged and Older Chinese: Evidence from the National Baseline Survey of CHARLS. Health Econ 26:431-449
Ning, Meng; Zhang, Qiang; Yang, Min (2016) Comparison of self-reported and biomedical data on hypertension and diabetes: findings from the China Health and Retirement Longitudinal Study (CHARLS). BMJ Open 6:e009836
Zhao, Yaohui; Crimmins, Eileen M; Hu, Peifeng et al. (2016) Prevalence, diagnosis, and management of diabetes mellitus among older Chinese: results from the China Health and Retirement Longitudinal Study. Int J Public Health 61:347-56
Liu, Cong; Yang, Changyuan; Zhao, Yaohui et al. (2016) Associations between long-term exposure to ambient particulate air pollution and type 2 diabetes prevalence, blood glucose and glycosylated hemoglobin levels in China. Environ Int 92-93:416-421
Hu, Peifeng; Herningtyas, Elizabeth H; Kale, Varsha et al. (2015) External quality control for dried blood spot-based C-reactive protein assay: experience from the indonesia family life survey and the longitudinal aging study in India. Biodemography Soc Biol 61:111-20
Lei, Xiaoyan; Strauss, John; Tian, Meng et al. (2015) Living arrangements of the elderly in China: evidence from the CHARLS national baseline. China Economic J 8:191-214
Lei, Xiaoyan; Sun, Xiaoting; Strauss, John et al. (2014) Depressive symptoms and SES among the mid-aged and elderly in China: evidence from the China Health and Retirement Longitudinal Study national baseline. Soc Sci Med 120:224-32
Zhao, Yaohui; Hu, Yisong; Smith, James P et al. (2014) Cohort profile: the China Health and Retirement Longitudinal Study (CHARLS). Int J Epidemiol 43:61-8

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