Stress is part of daily life;in a national study 40% of respondents reported experiencing stress that day. We know from many studies that stress can affect health, memory, and well-being. But does it affect how we make decisions? And if so, what are the implications-do we become more or less risk averse? Are we more influenced by the potential downsides and less by potential upsides to an option than we would be otherwise? Making decisions involves a complex yet flexible set of brain mechanisms that compute the potential value of options and adjust that value based on the level of uncertainty about the outcome. In this proposal, we examine the effects of acute stress on the basic elements of decision making: the neural signals that predict and represent value, integrate the positive and negative aspects of options, and assess risk based on predicted volatility and uncertainty of options. We test two main hypotheses. The first is that stress makes rewarding stimuli even more attractive and salient, via dopaminergic effects in the ventral striatum. The second is that stress affects risk processing via the insula, but that it has different effects depending on one's sex and age. Some of our most important decisions must be made under stressful circumstances;thus it is paramount that we understand the basic mechanisms of how stress changes the way we evaluate decision options.

Public Health Relevance

Important decisions, such as those regarding personal finances and health care, often involve substantial stress, especially among older adults. The studies in this proposal will provide important information about how stress affects those decisions and how risk averse people are. Making optimal decisions is challenging even under the best of circumstances;these findings should provide critical information for understanding how to improve decision making under stress.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
5R01AG038043-05
Application #
8676612
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Nielsen, Lisbeth
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Southern California
Department
None
Type
Other Specialized Schools
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Clewett, David; Bachman, Shelby; Mather, Mara (2014) Age-related reduced prefrontal-amygdala structural connectivity is associated with lower trait anxiety. Neuropsychology 28:631-42
Barber, Sarah J; Mather, Mara (2014) How retellings shape younger and older adults' memories. J Cogn Psychol (Hove) 26:263-279
Clewett, David; Schoeke, Andrej; Mather, Mara (2014) Locus coeruleus neuromodulation of memories encoded during negative or unexpected action outcomes. Neurobiol Learn Mem 111:65-70
Lighthall, Nichole R; Gorlick, Marissa A; Schoeke, Andrej et al. (2013) Stress modulates reinforcement learning in younger and older adults. Psychol Aging 28:35-46
Clewett, David; Schoeke, Andrej; Mather, Mara (2013) Amygdala functional connectivity is reduced after the cold pressor task. Cogn Affect Behav Neurosci 13:501-18
Nashiro, Kaoru; Sakaki, Michiko; Mather, Mara (2012) Age differences in brain activity during emotion processing: reflections of age-related decline or increased emotion regulation? Gerontology 58:156-63
Mather, Mara; Lighthall, Nichole R (2012) Both Risk and Reward are Processed Differently in Decisions Made Under Stress. Curr Dir Psychol Sci 21:36-41
Lighthall, Nichole R; Sakaki, Michiko; Vasunilashorn, Sarinnapha et al. (2012) Gender differences in reward-related decision processing under stress. Soc Cogn Affect Neurosci 7:476-84
Mather, Mara; Sutherland, Matthew R (2011) Arousal-Biased Competition in Perception and Memory. Perspect Psychol Sci 6:114-33
Feng, Michelle C; Courtney, Christopher G; Mather, Mara et al. (2011) Age-related affective modulation of the startle eyeblink response: older adults startle most when viewing positive pictures. Psychol Aging 26:752-60