Alzheimer's disease (AD) is a major public health issue facing the world's aging population;however, to date, there is no rapid and cost effective means for early diagnosis that is widely accessible. It has been suggested that a blood-based screening will become the first-step in the AD diagnostic process, although no such test currently exists. In our prior work through the Texas Alzheimer's Research &Care Consortium (TARCC), we created a serum-based screening algorithm that correctly classified 94% of those with and without AD. We then followed that work-up by creating a blood-based algorithm in the TARCC that worked across both serum and plasma that, when applied to the ADNI plasma samples, correctly classified 89% of those with and without AD in the entirely independent cohort. The long-term goal of this project is the validation of the our blood-based screening instrument for AD.
The specific aims of the current project are as follows:
Specific Aim 1 : To test the reliability and validity of our previously created blood-based screening algorithm, and Specific Aim 2: To validate our blood-based algorithms against other diagnostic modalities (i.e., neuropathological findings and CSF analyses). Multiplex serum- and plasma-based biomarker assays (using electrochemiluminescence) will be conducted on 1,100 samples from the TARCC and Mayo Clinic Jacksonville biobanks. The establishment of a blood-based screening instrument for AD will significantly change the field of geriatric medicine. Such a tool would fit into the existing medical infrastructure as a frontline population-based screening device where positive findings can be followed-up with clinical, imaging or CSF assessments. This overall approach will increase accessibility to standard care far beyond what can be offered by other methodologies. This approach will also provide a more rapid and cost-efficient means for screening into AD clinical trials.
Alzheimer's disease (AD) is a major public health issue facing the world's aging population;however, to date, there is no rapid and cost effective means for screening all those at risk for having the disease. The relevance of the current proposal is the establishment of a blood-based screener for AD that can be used and implemented as a frontline assessment device for clinical and research purposes. The establishment of a blood-based screener for AD would change the field of geriatric medicine and increase access to care globally.
|Henriksen, Kim; O'Bryant, Sid E; Hampel, Harald et al. (2014) The future of blood-based biomarkers for Alzheimer's disease. Alzheimers Dement 10:115-31|
|Edwards, Melissa; Balldin, Valerie Hobson; Hall, James et al. (2014) Combining select neuropsychological assessment with blood-based biomarkers to detect mild Alzheimer's disease: a molecular neuropsychology approach. J Alzheimers Dis 42:635-40|
|Falkowski, Jed; Atchison, Timothy; Debutte-Smith, Maxine et al. (2014) Executive functioning and the metabolic syndrome: a project FRONTIER study. Arch Clin Neuropsychol 29:47-53|
|Cunningham, Rebecca L; Singh, Meharvan; O'Bryant, Sid E et al. (2014) Oxidative stress, testosterone, and cognition among Caucasian and Mexican-American men with and without Alzheimer's disease. J Alzheimers Dis 40:563-73|
|O'Bryant, Sid E; Xiao, Guanghua; Zhang, Fan et al. (2014) Validation of a serum screen for Alzheimer's disease across assay platforms, species, and tissues. J Alzheimers Dis 42:1325-35|
|O'Bryant, Sid E; Xiao, Guanghua; Barber, Robert et al. (2014) Molecular neuropsychology: creation of test-specific blood biomarker algorithms. Dement Geriatr Cogn Disord 37:45-57|
|Edwards, Melissa; Hall, James; Gong, Gordon et al. (2014) Arsenic exposure, AS3MT polymorphism, and neuropsychological functioning among rural dwelling adults and elders: a cross-sectional study. Environ Health 13:15|
|Johnson, Leigh A; Cushing, Blair; Rohlfing, Geoffrey et al. (2014) The Hachinski ischemic scale and cognition: the influence of ethnicity. Age Ageing 43:364-9|
|Roane, Brandy M; Johnson, Leigh; Edwards, Melissa et al. (2014) The link between sleep disturbance and depression among Mexican Americans: a Project FRONTIER study. J Clin Sleep Med 10:427-31|
|Edwards, Melissa; Johnson, Leigh; Mauer, Cortney et al. (2014) Regional specific groundwater arsenic levels and neuropsychological functioning: a cross-sectional study. Int J Environ Health Res 24:546-57|
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