Cerebrovascular disease is among the most common neurological diseases of aging and is increasing in prevalence with changing demographic trends. The two most common consequences of cerebrovascular disease are cognitive and motor decline, which are major contributors to poor health outcomes and mortality. Identifying associated factors, particularly ones for which treatments are available, is a priority for researchers in aging. Recent data suggest that antiphospholipid antibodies (aPL) increase in aging, and are present in about 35% of persons over the age of 80 years. While aPL increase risk of stroke by about two-fold, their relation to decline in cognitive and motor function, perhaps through an association with both clinical and subclinical cerebrovascular disease, is unclear. The proposed epidemiologic study will take advantage of a cohort of 1,100 community-dwelling women and men who are followed longitudinally with a high follow-up rate, and who come to autopsy with a high autopsy rate (R01AG17917), to test the hypotheses that aPL are related to cognitive and motor decline. The study will also examine the relation of aPL to cerebrovascular disease, including subclinical cerebrovascular disease assessed by complementary ante-mortem neuroimaging and postmortem neuropathology, and the extent to which aPL are related to cognitive and motor impairment after controlling for this disease. This would suggest the existence of neurobiologic mechanisms other than cerebrovascular disease linking aPL and cognitive and motor dysfunction. Finally, because factors with effects other than vascular may influence relations, the study will examine the role of makers of inflammation and altered blood-brain barrier permeability. The proposed study, relating aPL and other markers to cognitive and motor decline, and cerebrovascular disease in older, community-dwelling persons, will provide new knowledge regarding the role of aPL in common neurological conditions of aging. Because aPL are common vascular factors for which treatments are available, this study will provide new data which has the potential to improve public health by shifting current clinical practice paradigms and reducing the burden of neurological disease in aging.

Public Health Relevance

Cerebrovascular disease is increasing in prevalence with the aging population, and cognitive and motor decline, its'two most common consequences, are both major contributors to poor health outcomes and mortality. Identification of associated factors is priority for researchers in aging. This study relating blood vascular factors to cognitive and motor decline, and cerebrovascular disease, will fill a gap in knowledge in the field and has potential to provide data which will improve public health. an important

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Neurological, Aging and Musculoskeletal Epidemiology Study Section (NAME)
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Anderson, Dallas
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Rush University Medical Center
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Song, Wei; Zukor, Hillel; Liberman, Adrienne et al. (2014) Astroglial heme oxygenase-1 and the origin of corpora amylacea in aging and degenerating neural tissues. Exp Neurol 254:78-89
Rao, Neal M; Levine, Steven R; Gornbein, Jeffrey A et al. (2014) Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the National Institute of Neurological Disorders and Stroke tissue-type plasminogen activator trials. Stroke 45:2728-33
Brandler, Ethan S; Sharma, Mohit; Sinert, Richard H et al. (2014) Prehospital stroke scales in urban environments: a systematic review. Neurology 82:2241-9
Fleischman, Debra A; Leurgans, Sue; Arfanakis, Konstantinos et al. (2014) Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition. Brain Struct Funct 219:2029-49
Crystal, Howard A; Schneider, Julie A; Bennett, David A et al. (2014) Associations of cerebrovascular and Alzheimer's disease pathology with brain atrophy. Curr Alzheimer Res 11:309-16
Buchman, A S; Bennett, D A (2013) Cognitive frailty. J Nutr Health Aging 17:738-9
Hausdorff, Jeffrey M; Buchman, Aron S (2013) What links gait speed and MCI with dementia? A fresh look at the association between motor and cognitive function. J Gerontol A Biol Sci Med Sci 68:409-11
Buchman, Aron S; Yu, Lei; Boyle, Patricia A et al. (2013) Microvascular brain pathology and late-life motor impairment. Neurology 80:712-8
Barnes, L L; Arvanitakis, Z; Yu, L et al. (2013) Apolipoprotein E and change in episodic memory in blacks and whites. Neuroepidemiology 40:211-9
Arvanitakis, Zoe; Brey, Robin L; Rand, Jacob H et al. (2013) Antiphospholipid antibodies, brain infarcts, and cognitive and motor decline in aging (ABICMA): design of a community-based, longitudinal, clinical-pathological study. Neuroepidemiology 40:73-84

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