Our MOBILIZE Boston Study (MBS) research supports our thesis that chronic pain in older persons directly contributes to an unexplained increase in risk for falls. Our results show that chronic multisite pain, reported by 40% of MBS participants at baseline, is independently associated with an increased rate of falls during the 18 month follow-up compared to those without pain. The results show that the role of pain as a contributor to falls is independent of balance, strength, and mobility limitations such as slow gait. Based on accumulating evidence ofthe role of cognition in mobility in older adults coupled with research showing brain and cognitive changes with chronic pain, we propose a new mode! of a cognitively-mediated pathway whereby pain and associated changes in the brain contribute to reduced attentional capacity and dual task mobility limitations and subsequently to falls in older adults. This new ROI project, the next step following the conclusion ofthe NlA-funded Research Nursing Home Program Project, known as the MOBILIZE Boston Study (MBS), will study an estimated 500 continuing members of our population-based cohort of older persons living in the Boston area.
Our specific aims are: 1) to investigate whether chronic pain contributes to poorer performance in tests of attention in the older population of the MBS;2) to investigate whether chronic pain is associated with gait alterations measured in single and dual task gait tests involving cognitive challenges;3) to investigate whether the relationship between chronic pain and falls is influenced by attention and performance on dual task gait tests;and 4) to conduct a pilot investigation of regional brain structure and volume measured by MRI in 50 older adults who have multisite pain compared to 50 older persons who have no pain, randomly selected from the MOBILIZE Boston cohort. For the aims, we will perform multivariable analyses using linear regression and negative binomial modeling. The long-term goal ofthe research is to develop clinical and research targets for new interventions to reduce risk of falls among older adults with chronic pain, and ultimately to improve clinical and rehabilitative care.

Public Health Relevance

The major premise for this study is that chronic pain is associated with changes in the brain that alter cognition and, in turn, compromise attentional resources leading to gait changes and ultimately increasing risk for falls. In this new ROI, the next step in the pain and falls project (Project 3) of the Research Nursing Home Program Project, (the MOBILIZE Boston Study), we will study a proposed cognitively-mediated pathway from pain to falls in the older population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG041525-02
Application #
8290315
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1 (04))
Program Officer
Joseph, Lyndon
Project Start
2011-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2012
Total Cost
$599,578
Indirect Cost
$54,279
Name
University of Massachusetts Boston
Department
None
Type
Schools of Nursing
DUNS #
808008122
City
Boston
State
MA
Country
United States
Zip Code
02125
Eggermont, Laura H P; Leveille, Suzanne G; Shi, Ling et al. (2014) Pain characteristics associated with the onset of disability in older adults: the maintenance of balance, independent living, intellect, and zest in the Elderly Boston Study. J Am Geriatr Soc 62:1007-16
Thakral, Manu; Shi, Ling; Shmerling, Robert H et al. (2014) A stiff price to pay: does joint stiffness predict disability in an older population? J Am Geriatr Soc 62:1891-9
Eum, Regina; Leveille, Suzanne G; Kiely, Dan K et al. (2013) Is kyphosis related to mobility, balance, and disability? Am J Phys Med Rehabil 92:980-9