Most adults over the age of 65 and a growing number in mid-life are living with two or more chronic medical conditions ("multimorbidity"), and multimorbidity is strongly associated with risk of subsequent disability and mortality. Increasing attention is being devoted to identifying those adults who are most vulnerable to adverse outcomes and to treating their multiple conditions effectively, and by far the bulk of this researc centers on factors that increase the risk of multimorbidity burden and the likelihood that multimorbidity will result in functional declines. The proposed research is designed to address two significant gaps in the multimorbidity literature. The first is the potential role of psychosocal resources in preventing or delaying multimorbidity in aging adults and in protecting against functional declines and greater mortality that are typically associated with multimorbidity. The second is a biopsychosocial perspective that recognizes that multimorbidity and its consequences are likely to involve complex interactions of social, psychological, and biological processes. We focus on two psychosocial resources - a strong sense of purpose in life and positive social relationships - that we and others have linked to better health outcomes and reduced mortality in clinical sample and large epidemiological studies. We propose to examine the contribution of psychosocial resources to (a) reduced and/or delayed development of multimorbidity burden and (b) reduced or delayed declines in functional and cognitive abilities and in mortality in adults with multimorbidity. We will also examine the extent to which psychosocial resources are linked to reductions in multimorbidity, functional declines, and mortality in aging adults at greater risk of all of these outcomes due to sociodemographic risk factors (e.g. age, female gender, low educational attainment). Finally, consistent with our integrative perspective, we will examine the role of a well-defined biological process - inflammation - as a potential mediator of (a) the links between multimorbidity and functional and mortality outcomes and (b) psychosocial moderation of the links between multimorbidity and these outcomes. That is, we hypothesize that psychosocial resources will act through reduced circulating levels of inflammatory proteins to weaken the link between multimorbidity and adverse outcomes, thereby enabling aging adults to live well with multimorbidity. We will test these hypotheses using data from three waves of the Survey of Mid-Life in the United States (MIDUS). MIDUS is the ideal forum for our analyses, as it brings together high quality assessments of health, psychosocial functioning, and biological processes related to health in a large population-based study. The longitudinal structure of MIDUS will enable us to examine change over time in predictors, outcomes, and their associations, and our analytical approach will use multilevel models and moderated mediation analyses to provide precise tests of our key hypotheses. Finally, as the psychosocial resources that lie at the heart of the application are modifiable, the results of this study will point directly to novel ways to improve health and well-being in adults with multimorbidity.

Public Health Relevance

It is becoming increasingly common for older adults to be living longer with multiple chronic medical conditions, and while having multiple conditions often leads to declines in physical and mental abilities, there are many older adults who manage to live active and engaged lives despite their health problems. We will examine the role of psychosocial resources - a strong sense of purpose in life and positive social relationships - in helping older adults to retain their functional abilities despite having multiple chronic condition, and we will link these resources to a specific biological pathway - inflammation - that has well-established associations with health in later life. The results of this study will point to novel approaches to improving health in older adults and in the growing number of middle-aged adults who suffer chronic conditions more commonly associated with later life.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG041750-01A1
Application #
8506166
Study Section
Social Psychology, Personality and Interpersonal Processes Study Section (SPIP)
Program Officer
Nielsen, Lisbeth
Project Start
2013-06-15
Project End
2018-05-31
Budget Start
2013-06-15
Budget End
2014-05-31
Support Year
1
Fiscal Year
2013
Total Cost
$243,075
Indirect Cost
$79,075
Name
Purdue University
Department
Miscellaneous
Type
Schools of Public Health
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907