The overall aim of this submission is to examine if cognitive functioning in MCI can be improved with training exercises. These findings could further our understanding about the mechanisms of MCI, inform our attempts to intervene in this disease, and influence the design and methodology of future clinical trials. We propose a randomized, placebo-controlled, clinical trial using [230] older adults with MCI. Following pre-testing with a cognitive battery, participants will be randomly assigned to either the experimental group or an active control group. Those in the experimental group will complete 40 1-hour sessions of online, computerized exercises designed to improve processing speed and auditory memory (Brain Plasticity, Inc.). Those in the control group will complete 40 1-hour sessions of online, computerized activities that are not specifically designed to improve cognition (e.g., crossword puzzles). Post-testing will follow completion of training in both groups. We will also examine effects of the training program after 12 months. By achieving these aims, we expect to advance our understanding of the mechanisms and treatment of MCI, which will have effects for clinical care and research. For example, if these individuals do benefit from cognitive training, then this may reduce the disability associated with this disease. This project is consistent with the mission of the National Institute on Aging. Relevance. Minimizing the deleterious effects of MCI is critical for providing clinical care and advancing research with this disease. For example, if cognitive deficits can be minimized, then individuals may retain functional independence for longer periods of time. Similarly, awareness of factors that moderate the effects of intervention will allow us to target individuals for future clinical trials in MCI.

Public Health Relevance

Although cognitive decline seems to be part of normal aging, recent research suggests that processing speed and memory can be improved with training. Improvements in cognition may have beneficial effects on daily functioning in older adults. Results of the current proposal may provide information about the efficacy of this particular intervention, as well as variables that moderate treatment response. As such, these results may inform clinical practice and research for patients with MCI.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG045163-01A1
Application #
8696570
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Ryan, Laurie M
Project Start
2014-05-15
Project End
2019-01-31
Budget Start
2014-05-15
Budget End
2015-01-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Utah
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
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Duff, Kevin; Suhrie, Kayla R; Dalley, Bonnie C A et al. (2018) External validation of change formulae in neuropsychology with neuroimaging biomarkers: a methodological recommendation and preliminary clinical data. Clin Neuropsychol :1-12
Duff, Kevin; Anderson, Jeffrey S; Mallik, Atul K et al. (2018) Short-term repeat cognitive testing and its relationship to hippocampal volumes in older adults. J Clin Neurosci 57:121-125
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Duff, Kevin; Atkinson, Taylor J; Suhrie, Kayla R et al. (2017) Short-term practice effects in mild cognitive impairment: Evaluating different methods of change. J Clin Exp Neuropsychol 39:396-407
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Hammers, Dustin B; Atkinson, Taylor J; Dalley, Bonnie C A et al. (2017) Amyloid Positivity Using [18F]Flutemetamol-PET and Cognitive Deficits in Nondemented Community-Dwelling Older Adults. Am J Alzheimers Dis Other Demen 32:320-328
Duff, Kevin (2016) Demographically corrected normative data for the Hopkins Verbal Learning Test-Revised and Brief Visuospatial Memory Test-Revised in an elderly sample. Appl Neuropsychol Adult 23:179-85