Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG047116-03
Application #
8878979
Study Section
Special Emphasis Panel (ZAG1-ZIJ-6 (J3))
Program Officer
Yang, Austin Jyan-Yu
Project Start
2013-09-01
Project End
2017-06-30
Budget Start
2015-07-15
Budget End
2016-06-30
Support Year
3
Fiscal Year
2015
Total Cost
$429,015
Indirect Cost
$138,015
Name
University of California Santa Barbara
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
094878394
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106
Do, Thanh D; Sangwan, Smriti; de Almeida, Natália E C et al. (2018) Distal amyloid ?-protein fragments template amyloid assembly. Protein Sci 27:1181-1190
Bleiholder, Christian; Bowers, Michael T (2017) The Solution Assembly of Biological Molecules Using Ion Mobility Methods: From Amino Acids to Amyloid ?-Protein. Annu Rev Anal Chem (Palo Alto Calif) 10:365-386
de Almeida, Natália E C; Do, Thanh D; LaPointe, Nichole E et al. (2017) 1,2,3,4,6-penta-O-galloyl-?-D-glucopyranose Binds to the N-terminal Metal Binding Region to Inhibit Amyloid ?-protein Oligomer and Fibril Formation. Int J Mass Spectrom 420:24-34
Sangwan, Smriti; Zhao, Anni; Adams, Katrina L et al. (2017) Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A 114:8770-8775
de Almeida, Natália E C; Do, Thanh D; Tro, Michael et al. (2016) Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-Penta-O-galloyl-?-d-glucopyranose on Amyloid ?25-35 Assembly. ACS Chem Neurosci 7:218-26
Feinstein, H Eric; Benbow, Sarah J; LaPointe, Nichole E et al. (2016) Oligomerization of the microtubule-associated protein tau is mediated by its N-terminal sequences: implications for normal and pathological tau action. J Neurochem 137:939-54
Zheng, Xueyun; Wu, Chun; Liu, Deyu et al. (2016) Mechanism of C-Terminal Fragments of Amyloid ?-Protein as A? Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity? J Phys Chem B 120:1615-23
Do, Thanh D; LaPointe, Nichole E; Nelson, Rebecca et al. (2016) Amyloid ?-Protein C-Terminal Fragments: Formation of Cylindrins and ?-Barrels. J Am Chem Soc 138:549-57
Economou, Nicholas J; Giammona, Maxwell J; Do, Thanh D et al. (2016) Amyloid ?-Protein Assembly and Alzheimer's Disease: Dodecamers of A?42, but Not of A?40, Seed Fibril Formation. J Am Chem Soc 138:1772-5
Eschmann, Neil A; Do, Thanh D; LaPointe, Nichole E et al. (2015) Tau Aggregation Propensity Engrained in Its Solution State. J Phys Chem B 119:14421-32

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