Early adversity (EA) in humans is a major contributing factor to a range of deleterious physical and mental health outcomes extending through adulthood such as depression and anxiety, obesity and heart disease, and premature death. In addition to detracting significantly from individual well-being and quality of life, these conditios also consume considerable resources from federal, state, and community organizations. The mechanisms through which EA exerts its effects on these outcomes are increasingly well understood, and include neurocognitive pathways related to executive function. An intervention that can successfully target, engage with, and alter the functioning of one or more of these mechanisms would be a promising way of mitigating the impact of EA on deleterious outcomes later in life. The proposed research focuses on one such pathway-deficits in inhibitory control (IC)-and tests the feasibility and efficacy of an intervention to increase functioning in that pathway in a sample of individuals who experienced EA. The intervention is grounded in a neurally informed model of change that specifies deficits in IC as an underlying causal factor common to several health-risking behaviors (HRBs). These IC deficits emerge during development as a result of a range of EA, and, critically, can be remediated in mid-life through targeted intervention. Research from our laboratory has validated an intervention that can increase IC performance and alter its underlying neural systems in young adults (Berkman, Kahn, &Merchant, 2014). The next step in this program of research, proposed here, is to test the efficacy of that intervention in a sample of mid-life individuals who have experienced EA and the extent to which our intervention generalizes to HRBs that are prevalent in that sample.
The first Aim i s to test whether the intervention alters the IC system in tasks both similar to and dissimilar from the training task in terms of both behavioral performance and neural functioning.
The second Aim i s to test whether alterations in the functioning of the underlying neural systems mediate the effect of the intervention on performance and The two Aims will be accomplished within the context of a single RCT with two arms (IC training vs. active control) and pre-post measurements of IC performance, IC neural systems, and HRBs. All participants (N = 110) come to the lab for an initial assessment of behavioral / neural measures of IC and HRBs, among other measures. Then, participants are randomly assigned to receive a Person-Centered Inhibitory Control (PeCIC) training or active control training, every other day for 3-4 weeks. The PeCIC systematically pairs IC engagement with alcohol, tobacco, and/or energy-dense food cues, depending on each participant's reports of disinhibited behavior in those domains. The active control task uses personalized cues and response time tasks but does not involve IC. Finally, participants return to the laboratory for an endpoint assessment where all baseline measures are repeated. The two Aims will be robustly tested in a series of analyses comparing the behavioral and neural change from pre- to post-intervention between the groups disinhibition-related HRBs.

Public Health Relevance

Insufficient inhibitory control is one pathway through which early adversity is related to a range of problems including excessive alcohol use, tobacco use, and unhealthy eating. The proposed research leverages a neurally informed model of inhibitory control and how it can be improved to test the efficacy of a person- centered inhibitory control intervention in a sample of mid-life individuals with early adversity. The knowledge obtained by this study could be scaled into a flexible, low-cost, and wide-ranging intervention to remediate some of the effects of early adversity on inhibitory control and thus a number of prevalent health risking behaviors.

National Institute of Health (NIH)
National Institute on Aging (NIA)
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Nielsen, Lisbeth
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University of Oregon
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Berkman, Elliot T; Hutcherson, Cendri A; Livingston, Jordan L et al. (2017) Self-Control as Value-Based Choice. Curr Dir Psychol Sci 26:422-428
Roos, Leslie E; Knight, Erik L; Beauchamp, Kathryn G et al. (2017) Acute stress impairs inhibitory control based on individual differences in parasympathetic nervous system activity. Biol Psychol 125:58-63
Patterson, Tara K; Lenartowicz, Agatha; Berkman, Elliot T et al. (2016) Putting the brakes on the brakes: negative emotion disrupts cognitive control network functioning and alters subsequent stopping ability. Exp Brain Res 234:3107-3118
Beauchamp, Kathryn G; Kahn, Lauren E; Berkman, Elliot T (2016) Does inhibitory control training transfer?: behavioral and neural effects on an untrained emotion regulation task. Soc Cogn Affect Neurosci 11:1374-82
Fisher, Philip A; Berkman, Elliot T (2015) Designing Interventions Informed by Scientific Knowledge About Effects of Early Adversity: A Translational Neuroscience Agenda for Next Generation Addictions Research. Curr Addict Rep 2:347-353
Giuliano, Ryan J; Skowron, Elizabeth A; Berkman, Elliot T (2015) Growth models of dyadic synchrony and mother-child vagal tone in the context of parenting at-risk. Biol Psychol 105:29-36
Giuliani, Nicole R; Tomiyama, A Janet; Mann, Traci et al. (2015) Prediction of daily food intake as a function of measurement modality and restriction status. Psychosom Med 77:583-90
Berkman, Elliot T; Lukinova, Evgeniya; Menshikov, Ivan et al. (2015) Sociality as a natural mechanism of public goods provision. PLoS One 10:e0119685
Giuliani, Nicole R; Berkman, Elliot T (2015) Craving is an Affective State and Its Regulation Can Be Understood in Terms of the Extended Process Model of Emotion Regulation. Psychol Inq 26:48-53
Inzlicht, Michael; Berkman, Elliot (2015) Six Questions for the Resource Model of Control (and Some Answers). Soc Personal Psychol Compass 9:511-524

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