Title: The Importance of Place of Birth in Determining Health and Mortality at Older Ages Substantial spatial inequalities in old age health and mortality outcomes are well documented. Previous studies have linked old age health to contemporaneous spatial context. However, by old age, over a third of the popu- lation has left their state of birth and an even greater share has left their county of birth, leaving the interpreta- tion of contemptuous links between geography and health clouded by endogenous mobility and disregarding the importance of childhood exposures in producing the spatial inequalities in health across the life course and into old age. Successfully unraveling the importance of life course exposures and decisions producing old age spatial inequalities has the potential to contribute to basic science as well as policy, but efforts have been ham- pered by a lack of large datasets with place of birth information. Our proposal takes advantage of newly avail- able data on place of birth for over 5 million Americans born across the early to mid 20PthP century combined with our team's interdisciplinary background merging the demography, economics, population health, and epidemi- ology of old age morbidity and mortality processes. UOur overall aim is to uncover the extent to which place of birth has contributed to old age health inequalities by birth cohort, race/ethnicity, sex, and educa- tional attainment in the US, and to explore the mechanisms underlying these relationshipsU. Our re- search team will leverage newly released and unique longitudinal data on millions of individuals across multiple datasets containing rich measures of health processes in old age and mechanisms of early disease exposures, cumulative contextual disadvantage, and life course mobility. Using these data, we will Upursue the following aimsU: (1) Aim 1: Create an ?Atlas of Birth Place Impacts on Mortality and Morbidity at Older Ages?, (2) Deter- mine the Influence of Birth Place on Health Disparities and Mortality Variation at Older Ages by sex, race/eth- nicity, and education and (3) Uncover mechanisms linking the relationship between place of birth and later health by focusing on mobility and early and cumulative exposures. Together, these aims will allow a paradigm shift in how we understand old age health processes by integrating life course and spatial analysis into large scale analyses of the patterns and mechanisms of old age health and mortality.

Public Health Relevance

This project aims to increase understanding of the impacts of early life geographic context on the levels of and variation of old age health, disability, and mortality by using newly available data on millions of individuals linked to their state/county of birth over the 20PthP century. It identifies the contribution of environment experienced in childhood to variation in health late in life by birth cohort, race/ethnicity, sex, and educational attainment. It also explores how early disease environments, cumulative contextual disadvantages, and life course mobility affect old age health outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG060109-01
Application #
9589600
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Karraker, Amelia Wilkes
Project Start
2018-09-01
Project End
2023-06-30
Budget Start
2018-09-01
Budget End
2019-06-30
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715