We propose to continue and greatly extend our studies on the molecular biology of picornaviruses, particularly on poliovirus. We shall study aspects of viral protein synthesis (initiation and processing of polypeptides) and the intriguing problem of viral RNA replication. We will use recombinant DNA technology to define gene function (in vitro recombination, site specific mutagenesis) and we plan to characterize the surface properties of the virion (neutralizing epitopes, virus-cell attachment sites). Our studies may lead to the development of new vaccines and drugs directed against picornavirus infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI015122-12
Application #
3126017
Study Section
Experimental Virology Study Section (EVR)
Project Start
1978-04-01
Project End
1988-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
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