Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI016943-14
Application #
3126920
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1980-03-01
Project End
1993-08-31
Budget Start
1993-03-01
Budget End
1993-08-31
Support Year
14
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Carcache, David A; Cho, Young Shin; Hua, Zihao et al. (2006) Total synthesis of (+/-)-jiadifenin and studies directed to understanding its SAR: probing mechanistic and stereochemical issues in palladium-mediated allylation of enolate-like structures. J Am Chem Soc 128:1016-22
Hua, Zihao; Carcache, David A; Tian, Yuan et al. (2005) The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187. J Org Chem 70:9849-56
Keding, Stacy J; Danishefsky, Samuel J (2004) Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors. Proc Natl Acad Sci U S A 101:11937-42
Cho, Young Shin; Carcache, David A; Tian, Yuan et al. (2004) Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. J Am Chem Soc 126:14358-9
Dudkin, Vadim Y; Miller, Justin S; Danishefsky, Samuel J (2004) Chemical synthesis of normal and transformed PSA glycopeptides. J Am Chem Soc 126:736-8
Krug, Lee M; Ragupathi, Govind; Hood, Chandra et al. (2004) Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin. Clin Cancer Res 10:6094-100
Warren, J David; Miller, Justin S; Keding, Stacy J et al. (2004) Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. J Am Chem Soc 126:6576-8
Gaul, Christoph; Njardarson, Jon T; Danishefsky, Samuel J (2003) The total synthesis of (+)-migrastatin. J Am Chem Soc 125:6042-3
Miller, Justin S; Dudkin, Vadim Y; Lyon, Gholson J et al. (2003) Toward fully synthetic N-linked glycoproteins. Angew Chem Int Ed Engl 42:431-4
Coltart, Don M; Royyuru, Ajay K; Williams, Lawrence J et al. (2002) Principles of mucin architecture: structural studies on synthetic glycopeptides bearing clustered mono-, di-, tri-, and hexasaccharide glycodomains. J Am Chem Soc 124:9833-44

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