Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI022848-11
Application #
2062011
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1986-07-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Gupta, R K; Collier, R J; Rappuoli, R et al. (1997) Differences in the immunogenicity of native and formalinized cross reacting material (CRM197) of diphtheria toxin in mice and guinea pigs and their implications on the development and control of diphtheria vaccine based on CRMs. Vaccine 15:1341-3
Blanke, S R; Milne, J C; Benson, E L et al. (1996) Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen. Proc Natl Acad Sci U S A 93:8437-42
Oh, K J; Zhan, H; Cui, C et al. (1996) Organization of diphtheria toxin T domain in bilayers: a site-directed spin labeling study. Science 273:810-2
Ballard, J D; Collier, R J; Starnbach, M N (1996) Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo. Proc Natl Acad Sci U S A 93:12531-4
Marsischky, G T; Wilson, B A; Collier, R J (1995) Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins. J Biol Chem 270:3247-54
Milne, J C; Blanke, S R; Hanna, P C et al. (1995) Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus. Mol Microbiol 15:661-6
Zhan, H; Oh, K J; Shin, Y K et al. (1995) Interaction of the isolated transmembrane domain of diphtheria toxin with membranes. Biochemistry 34:4856-63
Wilson, B A; Blanke, S R; Reich, K A et al. (1994) Active-site mutations of diphtheria toxin. Tryptophan 50 is a major determinant of NAD affinity. J Biol Chem 269:23296-301
Zhan, H; Choe, S; Huynh, P D et al. (1994) Dynamic transitions of the transmembrane domain of diphtheria toxin: disulfide trapping and fluorescence proximity studies. Biochemistry 33:11254-63
Mindell, J A; Zhan, H; Huynh, P D et al. (1994) Reaction of diphtheria toxin channels with sulfhydryl-specific reagents: observation of chemical reactions at the single molecule level. Proc Natl Acad Sci U S A 91:5272-6

Showing the most recent 10 out of 53 publications