Immunobiology of Genital HSV-2 Infection

Bernstein, David I.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 7R01AI023482-10
• Application #: 2062217
• Study Section: Experimental Virology Study Section (EVR)
• Project Start: 1987-01-01
• Project End: 1996-12-31
• Budget Start: 1995-10-01
• Budget End: 1996-12-31
• Support Year: 10
• Fiscal Year: 1995

Institution

• Name: Cincinnati Children's Hospital Medical Center
• DUNS #: 071284913
• City: Cincinnati
• State: OH
• Country: United States
• Zip Code: 45229

Publications

Milligan, G N; Bernstein, D I (1997) Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract. Virology 229:259-68

Bourne, N; Stanberry, L R; Bernstein, D I et al. (1996) DNA immunization against experimental genital herpes simplex virus infection. J Infect Dis 173:800-7

Bourne, N; Milligan, G N; Schleiss, M R et al. (1996) DNA immunization confers protective immunity on mice challenged intravaginally with herpes simplex virus type 2. Vaccine 14:1230-4

Milligan, G N; Bernstein, D I (1995) Generation of humoral immune responses against herpes simplex virus type 2 in the murine female genital tract. Virology 206:234-41

Bernstein, D I; Harrison, C J; Tepe, E R et al. (1995) Effect of imiquimod as an adjuvant for immunotherapy of genital HSV in guinea-pigs. Vaccine 13:72-6

Harrison, C J; Miller, R L; Bernstein, D I (1994) Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs. Antimicrob Agents Chemother 38:2059-64

Bernstein, D I; Miller, R L; Harrison, C J (1993) Effects of therapy with an immunomodulator (imiquimod, R-837) alone and with acyclovir on genital HSV-2 infection in guinea-pigs when begun after lesion development. Antiviral Res 20:45-55

McLean, J H; Shipley, M T; Bernstein, D I et al. (1993) Selective lesions of neural pathways following viral inoculation of the olfactory bulb. Exp Neurol 122:209-22

Connelly, B L; Stanberry, L R; Bernstein, D I (1993) Detection of varicella-zoster virus DNA in nasopharyngeal secretions of immune household contacts of varicella. J Infect Dis 168:1253-5

Bernstein, D I; Miller, R L; Harrison, C J (1993) Adjuvant effects of imiquimod on a herpes simplex virus type 2 glycoprotein vaccine in guinea pigs. J Infect Dis 167:731-5