Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI028398-01
Application #
3142905
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1989-07-01
Project End
1992-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Hahnemann University
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Vaidya, Akhil B (2018) Reflections on an inflection: From virology to parasitology guided by POLARIS. PLoS Pathog 14:e1006941
Ke, Hangjun; Dass, Swati; Morrisey, Joanne M et al. (2018) The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion in Plasmodium falciparum. J Biol Chem 293:8128-8137
Ke, Hangjun; Morrisey, Joanne M; Qu, Shiwei et al. (2017) Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity. Antimicrob Agents Chemother 61:
Frueh, Lisa; Li, Yuexin; Mather, Michael W et al. (2017) Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria. ACS Infect Dis 3:728-735
Bushell, Ellen; Gomes, Ana Rita; Sanderson, Theo et al. (2017) Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Cell 170:260-272.e8
Jenkins, Bethany J; Daly, Thomas M; Morrisey, Joanne M et al. (2016) Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p. PLoS One 11:e0152197
Stickles, Allison M; Smilkstein, Martin J; Morrisey, Joanne M et al. (2016) Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria. Antimicrob Agents Chemother 60:4853-9
Miley, Galen P; Pou, Sovitj; Winter, Rolf et al. (2015) ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria. Antimicrob Agents Chemother 59:5555-60
Stickles, Allison M; Ting, Li-Min; Morrisey, Joanne M et al. (2015) Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy. Am J Trop Med Hyg 92:1195-201
Ke, Hangjun; Lewis, Ian A; Morrisey, Joanne M et al. (2015) Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle. Cell Rep 11:164-74

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