Abstract

In the acquired immunodeficiency syndrome (AIDS) studies, some statistical problems are rather unique (cf., J.R. Anderson, 1989. Biometric Bulletin. Feb. Issue). New methods are needed to address these particular issues. Here, we propose to study five important statistical problems arising in AIDS trials. The results from this research should be quite useful in developing and analyzing AIDS studies. These problems are: a) Drug combinations for Phase I and Phase II studies; b) Analysis of repeated virologic measurements; c) Analysis of repeated ordered categorical response data: d) The adaptive randomization designs for clinical trials; and e) The robust inference for Cox's proportional hazards model.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
7R01AI029131-03
Application #
3143858
Study Section
Special Emphasis Panel (ARR (V1))
Project Start
1989-09-30
Project End
1993-01-31
Budget Start
1991-08-01
Budget End
1993-01-31
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Other Domestic Higher Education
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138