Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI029661-04
Application #
2065134
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1992-02-01
Project End
1997-01-31
Budget Start
1995-02-01
Budget End
1997-01-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Saarloos, M N; Sullivan, B L; Czerniewski, M A et al. (1997) Detection of HLA-DR associated with monocytotropic, primary, and plasma isolates of human immunodeficiency virus type 1. J Virol 71:1640-3
Saifuddin, M; Hedayati, T; Atkinson, J P et al. (1997) Human immunodeficiency virus type 1 incorporates both glycosyl phosphatidylinositol-anchored CD55 and CD59 and integral membrane CD46 at levels that protect from complement-mediated destruction. J Gen Virol 78 ( Pt 8):1907-11
Saarloos, M N; Koenig, R E; Spear, G T (1995) Elevated levels of iC3b and C4d, but not Bb, complement fragments from plasma of persons infected with human T cell leukemia virus (HTLV) with HTLV-I-associated myelopathy/tropical spastic paraparesis. J Infect Dis 172:1095-7
Saifuddin, M; Landay, A L; Ghassemi, M et al. (1995) HTLV-I activates complement leading to increased binding to complement receptor-positive cells. AIDS Res Hum Retroviruses 11:1115-22
Saarloos, M N; Lint, T F; Spear, G T (1995) Efficacy of HIV-specific and 'antibody-independent' mechanisms for complement activation by HIV-infected cells. Clin Exp Immunol 99:189-95
Saifuddin, M; Parker, C J; Peeples, M E et al. (1995) Role of virion-associated glycosylphosphatidylinositol-linked proteins CD55 and CD59 in complement resistance of cell line-derived and primary isolates of HIV-1. J Exp Med 182:501-9
Spear, G T; Lurain, N S; Parker, C J et al. (1995) Host cell-derived complement control proteins CD55 and CD59 are incorporated into the virions of two unrelated enveloped viruses. Human T cell leukemia/lymphoma virus type I (HTLV-I) and human cytomegalovirus (HCMV). J Immunol 155:4376-81
Munson, L G; Scott, M E; Landay, A L et al. (1995) Decreased levels of complement receptor 1 (CD35) on B lymphocytes in persons with HIV infection. Clin Immunol Immunopathol 75:20-5
Spear, G T; Ghassemi, M; Takefman, D M (1994) HIV-1 strain dependence of complement-mediated virolysis induced by recombinant CD4-IgG. J Acquir Immune Defic Syndr 7:100-1
Spear, G T; Takefman, D M; Sharpe, S et al. (1994) Antibodies to the HIV-1 V3 loop in serum from infected persons contribute a major proportion of immune effector functions including complement activation, antibody binding, and neutralization. Virology 204:609-15

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