The primary long-term objective of this research is to provide biomedical scientists with knowledge needed to accurately identify tick vectors of microorganisms on a worldwide basis and provide information on tick-host relationships, distributions, ecology, etc. This will be done by locating the U.S. National Tick Collection and its curators in a stable university setting surrounded by an extremely active and stimulating roup of medical entomologists organized into an Institute of Anthropodology and Parasitology. A secondary long-term goal is to create an environment conducive to training students in tick systematics. Tick-borne pathogens continue to threaten human and other animals on a global scale and incorrect identification of vectors of microorganisms can result in devastating consequences.
Specific aims of this research proposal are: (1) Conduct SEM studies of the nymphal stages of the genus Ixodes in the United States and produce a monograph on them including keys. This genus includes the major vectors of the Lyme disease spirochetes; (2) an SEM study of the immature stages of Amblyomma ticks serving as vectors of heartwater disease in Africa and the Caribbean area; (3) preparation of a handbook on the Rhipicephalus species of Africa. Rhipicephalus species transmit the agents of boutonneuse fever in man and East coast fever in animals, plus other pathogens; (4) a cladistic study of the higher taxa of ticks to generate an hypothesis of phylogenetic relationships; (5) a cladistic study at the sugeneric and species level of the medically important genus Hyalomma (vectors of Crimean Congo Hemorrhagic Fever) in Pakistan. Techniques will include light and phase contrast microscopy along with scanning electron microscopy; morphometric analysis using IBM- based image analysis systems with appropriate hardware and software; and cladistic analysis using both the PAUP (Phylogenetic Analysis Using Parsimony) and Hennig 86 algorithms.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
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Special Emphasis Panel (SSS (04))
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Georgia Southern University
Schools of Arts and Sciences
United States
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Lundie, Rachel J; Webb, Lauren M; Marley, Angela K et al. (2016) A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection. Immunol Cell Biol 94:400-10
Cook, Peter C; Owen, Heather; Deaton, Aimée M et al. (2015) A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells. Nat Commun 6:6920
Redpath, Stephen A; van der Werf, Nienke; MacDonald, Andrew S et al. (2015) Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase. Infect Immun 83:3881-9
Hoy, Anna M; Lundie, Rachel J; Ivens, Alasdair et al. (2014) Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection. PLoS Negl Trop Dis 8:e2701
Ferragine, Christine E; Walls, Colleen D; Davies, Stephen J (2013) Modulation of innate antigen-presenting cell function by pre-patent schistosome infection. PLoS Negl Trop Dis 7:e2136
Perona-Wright, Georgia; Lundie, Rachel J; Jenkins, Stephen J et al. (2012) Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction. J Immunol 188:2350-8
Salvador-RecatalĂ , Vicenta; Greenberg, Robert M (2012) Calcium channels of schistosomes: unresolved questions and unexpected answers. Wiley Interdiscip Rev Membr Transp Signal 1:85-93
Cook, Peter C; Jones, Lucy H; Jenkins, Stephen J et al. (2012) Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo. Proc Natl Acad Sci U S A 109:9977-82
Kasinathan, Ravi S; Greenberg, Robert M (2012) Pharmacology and potential physiological significance of schistosome multidrug resistance transporters. Exp Parasitol 132:2-6
Taft, Andrew S; Yoshino, Timothy P (2011) Cloning and functional characterization of two calmodulin genes during larval development in the parasitic flatworm Schistosoma mansoni. J Parasitol 97:72-81

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