Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI030073-05
Application #
2065432
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1990-08-01
Project End
1996-12-31
Budget Start
1994-06-01
Budget End
1996-12-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Scott, P; Hondowicz, B; Eaton, A et al. (1996) The role of IL-12 in regulation of T helper cell subsets in vivo. Lessons from experimental cutaneous leishmaniasis. Ann N Y Acad Sci 795:250-6
Vieira, L Q; Goldschmidt, M; Nashleanas, M et al. (1996) Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication. J Immunol 157:827-35
Li, J; Scott, P; Farrell, J P (1996) In vivo alterations in cytokine production following interleukin-12 (IL-12) and anti-IL-4 antibody treatment of CB6F1 mice with chronic cutaneous leishmaniasis. Infect Immun 64:5248-54
Nabors, G S; Afonso, L C; Farrell, J P et al. (1995) Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc Natl Acad Sci U S A 92:3142-6
Scharton-Kersten, T; Afonso, L C; Wysocka, M et al. (1995) IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol 154:5320-30
Scharton-Kersten, T; Scott, P (1995) The role of the innate immune response in Th1 cell development following Leishmania major infection. J Leukoc Biol 57:515-22
Scott, P; Scharton, T (1994) Interaction between the innate and the acquired immune system following infection of different mouse strains with Leishmania major. Ann N Y Acad Sci 730:84-92
Vieira, L Q; Hondowicz, B D; Afonso, L C et al. (1994) Infection with Leishmania major induces interleukin-12 production in vivo. Immunol Lett 40:157-61
Afonso, L C; Scharton, T M; Vieira, L Q et al. (1994) The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235-7
Scott, P (1993) IL-12: initiation cytokine for cell-mediated immunity. Science 260:496-7

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