Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031137-05
Application #
2066147
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1991-04-01
Project End
1998-08-31
Budget Start
1995-04-01
Budget End
1998-08-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Zhang, D H; Yang, L; Cohn, L et al. (1999) Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 11:473-82
Zhang, D H; Yang, L; Ray, A (1998) Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J Immunol 161:3817-21
Ray, P; Ghosh, S K; Zhang, D H et al. (1997) Repression of interleukin-6 gene expression by 17 beta-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor. FEBS Lett 409:79-85
Ray, P; Yang, L; Zhang, D H et al. (1997) Selective up-regulation of cytokine-induced RANTES gene expression in lung epithelial cells by overexpression of IkappaBR. J Biol Chem 272:20191-7
Zhang, D H; Cohn, L; Ray, P et al. (1997) Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem 272:21597-603
Siegel, M D; Zhang, D H; Ray, P et al. (1995) Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements. J Biol Chem 270:24548-55
Ray, A; Zhang, D H; Ray, P (1995) Antagonism of nuclear factor-kappa B functions by steroid hormone receptors. Biochem Soc Trans 23:952-8
Ray, A; Zhang, D H; Siegel, M D et al. (1995) Regulation of interleukin-6 gene expression by steroids. Ann N Y Acad Sci 762:79-87;discussion 87-8
Ray, A; Prefontaine, K E; Ray, P (1994) Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J Biol Chem 269:12940-6
Ray, A; Prefontaine, K E (1994) Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci U S A 91:752-6

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